Volume 6, Number 2—April 2000
The bdr Gene Families of the Lyme Disease and Relapsing Fever Spirochetes: Potential Influence on Biology, Pathogenesis, and Evolution
|Species||Associated disease||Arthropod vector||Bdr-related information|
|B.burgdorferi||Lyme disease, endemic worldwide||I. scapularis, I. ricinus, I. pacificus||All bdr-gene family members (18 total) have been identified in isolate B31G (30), bdr-alleles that are organized into 3 subfamilies (D,E,F) (25), the genes are carried on variably sized linear and circular plasmids (30)|
|B. afzelii||Lyme disease, Eurasia||I. ricinus, I. persulcatus||Single bdr gene has been sequenced (43), several Bdr-related proteins have been detected by immunoblot analysis (this report)|
|B.garinii||Lyme disease, Eurasia||I. ricinus, I. persulcatus||Bdr proteins detected by immunoblot analyses only (this report)|
|B. tanukii||Not associated with human disease||I. tanuki||Bdr proteins detected by immunoblot analyses only (this report)|
|B. turdae||Not associated with human disease||I. turdus||Bdr proteins detected by immunoblot analyses only (this report)|
|B. bissettii||Not associated with human disease||I. pacificus, I. scapularis, I. spinipalpis||Bdr proteins detected by immunoblot analyses only (this report)|
|B. andersonii||Not associated with human disease||I. dentatus||bdr genes detected by hybridization and Bdr-related proteins by immunoblot analyses (this report, data not shown)|
|B. valaisiana||Not associated with human disease||I. columnae, I. ricinus||Bdr proteins detected by immunoblot analyses only (this report)|
|B. japonica||Not associated with human disease||I. ovatus||Bdr proteins detected by immunoblot analyses only (this report)|
|B. hermsii||Endemic relapsing fever, United States||Onithodoros hermsii||Numerous bdr genes have been described and are carried on both linear and circular plasmids (25,46); several detected by immunoblot analyses Bdr proteins have been (this report) (44)|
|B. parkeri||Endemic relapsing fever, United States||Onithodoros parkeri||Two bdr-related genes have been sequenced (25), and others have been detected by hybridization with genes residing on both linear and circular plasmids (46); several Bdr proteins detected by immunoblot analyses (this report)|
|B. turicatae||Endemic relapsing fever, United States||O. turicata||At least nine bdr-related genes have been described and are present on linear plasmids ranging from 25 to 220 kb in size (24,46); several Bdr proteins have been detected by immunoblotting (this report) (24,44)|
|B. miyamotoi||Relapsing fever?||I. persulcatus||Bdr proteins detected by immunoblotting only (this report)|
|B. coriaceae||Epizootic bovine abortion, United States||O. coriaceus||bdr-related genes and proteins detected by hybridization (46) or immunoblotting (this report)|
|B. anserina||Avian spirochetosis, United States||Argas persicus||bdr-related sequences have been detected by hybridization (46), Bdr- related proteins were not detected in in vitro cultivated bacteria (this report)|
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