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Volume 7, Number 2—April 2001
4th Decennial International Conference on Nosocomial and Healthcare-Associated Infections
State of the Art

Molecular Approaches to Diagnosing and Managing Infectious Diseases: Practicality and Costs

Michael A. PfallerComments to Author 
Author affiliation: University of Iowa College of Medicine, Iowa City, Iowa, USA

Main Article

Table 1

FDA-approved molecular diagnostic tests for infectious diseasea

Test Method Companyb
Chlamydia trachomatis detection PCRc
Hybrid capture Roche
Neisseria gonorrhoeae detection LCR
Hybrid capture Abbott
C. trachomatis/N. gonorrhoeae 
screening/detection Hybridization
SDR Gen-Probe
Mycobacterium tuberculosis detection PCR
TMA Roche
HPV screening Hybrid capture Digene
CMV Hybrid capture
NASBA Digene
Organon Teknika
Grp A strep detection Hybridization Gen-Probe
HIV quantitation PCR Roche
Gardnerella, T. vaginalis, and Candida Hybridization Becton-Dickinson
Culture confirmation for bacteria and fungi Hybridization Gen-Probe

aThe table contains examples of commercially available methods and is not intended to be all-inclusive. Websites of the principle manufacturers are a useful source of the most up-to-date information.
bCompanies: Digene, Silver Spring, MD; Chiron, Emeryville, CA; Roche, Branchburg, NJ; Organon Teknika, Durham, NC; Murex/Abbott, Abbott Park, IL; Gen-Probe, San Diego, CA; Abbott, Abbott Park, IL; Becton-Dickinson, Cockeysville, MD.
cPCR = polymerase chain reaction; LCR = ligase chain reaction; TMA = transcription-mediated amplification; SDR = strand displacement reaction; NASBA = nucleic acid strand-based amplification.

Main Article

Page created: May 10, 2011
Page updated: May 10, 2011
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.