Volume 7, Number 3—June 2001
Synopsis
Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome
Shahid Husain, Marilyn M. Wagener, and Nina Singh
Table 1
Variables associated with early and late-onset Cryptococcus neoformans infection in organ transplant recipients
| Variable (no. of patients for whom data available) | Early onset (within 12 months) (%) | Late onset (>12 months) (%) | p value |
|---|---|---|---|
| Age (mean) | 42.2 yrs | 44.3 yrs | NSa |
| Type of transplant | 0.001 | ||
| Liver (20) | 75 | 25 | |
| Kidney (54) | 28 | 72 | |
| Heart (9) | 33 | 67 | |
| Lung (2) | 100 | 0 | |
| Cytomegalovirus (CMV) infection (2) | 50 | 50 | NS |
| No CMV infection (6) | 67 | 33 | |
| Prior rejection (16) | 50 | 50 | NS |
| No prior rejection (45) | 36 | 64 | |
| U.S. region | 0.004b | ||
| Northeast (24) | 67 | 33 | |
| West (19) | 32 | 68 | |
| Midwest (9) | 22 | 78 | |
| South (20) | 40 | 60 | |
| Other countries | |||
| Europe (7) | 28 | 71 | |
| Asia (3) | 33 | 67 | |
| Site involved | |||
| Lung (26) | 42 | 58 | NS |
| Central nervous system (57) | 40 | 60 | |
| Skin/osteoarticular (23) | 30 | 70 | |
| Death rate (84) | 34 | 41 |
aNS = not significant, p >0.05.
bNortheastern United States versus all other regions.
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