Volume 7, Number 5—October 2001
Dispatch
Mycobacterium tuberculosis Beijing Genotype Strains Associated with Febrile Response to Treatment
Reinout van Crevel*
, Ron H.H. Nelwan†, Wilma de Lenne*, Yelilsan Veeraragu‡, Adri G. van der Zanden§, Zulkifli Amin†, Jos W.M. van der Meer*, and Dick van Soolingen¶
, Ron H.H. Nelwan†, Wilma de Lenne*, Yelilsan Veeraragu‡, Adri G. van der Zanden§, Zulkifli Amin†, Jos W.M. van der Meer*, and Dick van Soolingen¶
Table
Drug resistance and patient characteristics by Mycbacterium tuberculosis genotype, Indonesia
| Genotype |
||
|---|---|---|
| Patient characteristics | Beijing, n=31 (%) | Other, n=61(%) |
| Male | 19 (61) | 35 (57) |
| Age in years, median (range) | 31 (19-68) | 29 (17-70) |
| BCG scar | 8 (26) | 14 (23) |
| Chest X-ray | ||
| cavities | 16 (52) | 29/55a (53) |
| bilateral disease | 24 (77) | 40/55 (73) |
| Febrile response to treatentb | 15 (48) | 13 (21) |
| Patient strain resistant toc | n = 27 (%) | n = 56 (%) |
| Isoniazid | 10 (37) | 11 (20) |
| Rifampicin | 2 (7) | 2 (4) |
| Pyrazinamide | 0 | 3 (5) |
| Ethambutol | 1 (4) | 3 (5) |
| Streptomycin | 4 (15) | 3 (5) |
| Any prescribed drug | 11 (39) | 14 (25) |
aSix chest X-rays in the non-Beijing group were evaluated by only one pulmonologist.
bSignificant difference between groups (Mann-Whitney U-test; p=0.02).
c Eighty-three isolates were available for drug susceptibility testing.
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