TY - JOUR AU - McNabb, Scott J. N. AU - Braden, Christopher R. AU - Navin, Thomas R. T1 - DNA Fingerprinting of Mycobacterium tuberculosis: Lessons Learned and Implications for the Future T2 - Emerging Infectious Disease journal PY - 2002 VL - 8 IS - 11 SP - 1314 SN - 1080-6059 AB - DNA fingerprinting of Mycobacterium tuberculosis—a relatively new laboratory technique—offers promise as a powerful aid in the prevention and control of tuberculosis (TB). Established in 1996 by the Centers for Disease Control and Prevention (CDC), the National Tuberculosis Genotyping Surveillance Network was a 5-year prospective, population-based study of DNA fingerprinting conducted from 1996 to 2000. The data from this study suggest multiple molecular epidemiologic and program management uses for DNA fingerprinting in TB public health practice. From these data, we also gain a clearer understanding of the overall diversity of M. tuberculosis strains as well as the presence of endemic strains in the United States. We summarize the key findings and the impact that DNA fingerprinting may have on future approaches to TB control. Although challenges and limitations to the use of DNA fingerprinting exist, the widespread implementation of the technique into routine TB prevention and control practices appears scientifically justified. KW - Mycobacterium tuberculosis KW - DNA fingerprinting KW - RFLP typing KW - restriction fragment length polymorphism KW - tuberculosis KW - United States DO - 10.3201/eid0811.020402 UR - https://wwwnc.cdc.gov/eid/article/8/11/02-0402_article ER - End of Reference