Volume 8, Number 12—December 2002
Research
Efficacy of Killed Virus Vaccine, Live Attenuated Chimeric Virus Vaccine, and Passive Immunization for Prevention of West Nile virus Encephalitis in Hamster Model
Table 2
WNV antibody response of hamsters after immunization with WNV killed virus vaccine (Fort Dodge) and challenge with the NY385-99 strain of WNVa,b
Animal no. | HI antibody titer | CF antibody titer | PRN antibody titerc |
---|---|---|---|
32 days after Ft. Dodge vaccine | |||
H-8440 | 1:40 | 1:40 | 1:20 |
H-8441 | 0d | 0 | <1:10 |
H-8442 | 1:20 | 1:40 | <1:10 |
H-8443 | 1:40 | 1:40 | 1:20 |
H-8445 | 1:40 | 1:40 | 1:20 |
H-8446 | 1:20 | 1:20 | 1:40 |
H-8447 | 1:20 | 1:20 | <1:10 |
H-8448 | 1:20 | 1:20 | <1:10 |
H-8449 | 1:40 | 1:20 | 1:10 |
6 days after challenge with WNV | |||
H-8440 | 1:80 | 1:80 | ND |
H-8441 | 1:320 | 1:160 | ND |
H-8442 | 1:40 | 1:40 | ND |
H-8443 | 1:40 | 1:40 | ND |
H-8445 | 1:320 | 1:160 | ND |
H-8446 | 1:80 | 1:40 | ND |
H-8447 | 1:320 | 1:160 | ND |
H-8448 |
1:160 |
1:80 |
ND |
H-8449 | 1:160 | 1:40 | ND |
aWNV, West Nile virus; HI, hemagglutination inhibition; CF, complement fixation; PRN, plaque reduction neutralization; ND, not done.
b104.0 50% tissue culture infective dose50 given intraperitoneally.
cHighest serum dilution producing >90% plaque inhibition.
d0 = <1:20.