TY - JOUR AU - Helms, Morten AU - Vastrup, Pernille AU - Gerner-Smidt, Peter AU - Mølbak, Kåre T1 - Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium T2 - Emerging Infectious Disease journal PY - 2002 VL - 8 IS - 5 SP - 490 SN - 1080-6059 AB - In a matched cohort study, we determined the death rates associated with drug resistance in Salmonella Typhimurium. We linked data from the Danish Surveillance Registry for Enteric Pathogens with the Civil Registration System and the Danish National Discharge Registry. By survival analysis, the 2-year death rates were compared with a matched sample of the general Danish population, after the data were adjusted for differences in comorbidity. In 2,047 patients with S. Typhimurium, 59 deaths were identified. Patients with pansusceptible strains of S. Typhimurium were 2.3 times more likely to die 2 years after infection than persons in the general Danish population. Patients infected with strains resistant to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline were 4.8 times (95% CI 2.2 to 10.2) more likely to die, whereas quinolone resistance was associated with a mortality rate 10.3 times higher than the general population. KW - Zoonoses KW - Salmonella KW - serotype Typhimurium KW - mortality KW - drug-resistance KW - quinolones KW - Denmark DO - 10.3201/eid0805.010267 UR - https://wwwnc.cdc.gov/eid/article/8/5/01-0267_article ER - End of Reference