TY - JOUR AU - Yu, Wen Leong AU - Pfaller, Michael A. AU - Winokur, Patricia L. AU - Jones, Ronald N. T1 - Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan T2 - Emerging Infectious Disease journal PY - 2002 VL - 8 IS - 5 SP - 522 SN - 1080-6059 AB - To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum β-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented. KW - Klebsiella pneumoniae KW - extended-spectrum β-lactamases KW - CTX-M enzymes KW - carbapenems KW - cefepime KW - Taiwan DO - 10.3201/eid0805.010346 UR - https://wwwnc.cdc.gov/eid/article/8/5/01-0346_article ER - End of Reference