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Volume 9, Number 6—June 2003

Histopathologic Features of Mycobacterium ulcerans Infection

Jeannette Guarner*Comments to Author , Jeanine Bartlett*, Ellen A. Spotts Whitney*, Pratima L. Raghunathan*, Ymkje Stienstra†, Kwame Asamoa‡, Samuel Etuaful§, Erasmus Klutse¶, Eric Quarshie#, Tjip S. van der Werf†, Winette T.A. van der Graaf†, C. Harold King**, and David A. Ashford*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Groningen University Hospital, the Netherlands; ‡Ministry of Health, Accra, Ghana; §St. Martins Catholic Hospital, Agroyesum, Ghana; ¶Dunkwa Government Hospital, Dunkwa, Ghana; #Presbyterian Hospital, Agogo, Ghana; **Emory University, Atlanta, Georgia, USA

Main Article

Table 4

Comparison of histopathologic features of preulcerative and ulcerative lesions in definite Buruli ulcer cases

Histopathologic feature Preulcerative no. (%) Ulcerative no. (%) p value
8 (42)
42 (78)


17 (85)


AFB in dermisb
8 (40)
10 (19)

Subcutaneous tissue

AFB in subcutisc
18 (78)
31 (56)

Acute inflammationd
22 (96)
50 (91)

Chronic inflammatione
4 (17)
27 (49)

Granulomasf 3 (13) 27 (49) 0.005

aTwo specimens did not have epidermis, and one did not have dermis.
bConsidered as presence of acid-fast bacili (AFB) in dermis.
cConsidered as intense versus mild AFB in subcutis.
dAcute inflammation considered as present versus absent.
eChronic inflammation considered as intense versus mild.
fGranulomas considered as present versus absent.

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Page updated: December 21, 2010
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