TY - JOUR AU - Messer, William B. AU - Gubler, Duane J. AU - Harris, Eva AU - Sivananthan, Kamalanayani AU - de Silva, Aravinda M. T1 - Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus T2 - Emerging Infectious Disease journal PY - 2003 VL - 9 IS - 7 SP - 800 SN - 1080-6059 AB - Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF. KW - Dengue KW - dengue hemorrhagic fever KW - dengue serotype 3 KW - flavivirus KW - molecular epidemiology KW - virus Phylogeny KW - emerging virus KW - Sri Lanka KW - East Africa KW - Latin America KW - research DO - 10.3201/eid0907.030038 UR - https://wwwnc.cdc.gov/eid/article/9/7/03-0038_article ER - End of Reference