TY - JOUR AU - Factor, Stephanie H. AU - Levine, Orin S. AU - Schwartz, Benjamin AU - Harrison, Lee H. AU - Farley, Monica M. AU - McGeer, Allison AU - Schuchat, Anne T1 - Invasive Group A Streptococcal Disease: Risk Factors for Adults T2 - Emerging Infectious Disease journal PY - 2003 VL - 9 IS - 8 SP - 970 SN - 1080-6059 AB - We conducted a case-control study to identify risk factors for invasive group A streptococcal (GAS) infections, which can be fatal. Case-patients were identified when Streptoccus pyogenes was isolated from a normally sterile site and control subjects (two or more) were identified and matched to case-patients by using sequential-digit telephone dialing. All participants were noninstitutionalized surveillance area residents, >18 years of age. Conditional logistic regression identified the risk factors for invasive GAS infection: in adults 18 to 44 years of age, exposure to one or more children with sore throats (relative risk [RR]=4.93, p=0.02), HIV infection (RR =15.01, p=0.04), and history of injecting drug use (RR=14.71, p=0.003); in adults >45 years of age, number of persons in the home (RR=2.68, p=0.004), diabetes (RR= 2.27, p=0.03), cardiac disease (RR=3.24, p=0.006), cancer (RR= 3.54, p=0.006), and corticosteroid use (RR=5.18, p=0.03). Thus, host and environmental factors increased the risk for invasive GAS disease. KW - Streptococcus pyogenes KW - group A streptococcal disease, invasive disease, risk factors, case-control, sequential-digit dialing KW - necrotizing fasciitis, streptococcal toxic shock syndrome, conditional logistic regression, research KW - United States DO - 10.3201/eid0908.020745 UR - https://wwwnc.cdc.gov/eid/article/9/8/02-0745_article ER - End of Reference