TY - JOUR AU - Tsui, Ping Tim AU - Kwok, Man Leung AU - Yuen, Hon AU - Lai, Sik To T1 - Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates T2 - Emerging Infectious Disease journal PY - 2003 VL - 9 IS - 9 SP - 1064 SN - 1080-6059 AB - Severe acute respiratory syndrome (SARS) poses a major threat to the health of people worldwide. We performed a retrospective case series analysis to assess clinical outcome and identify pretreatment prognostic correlates of SARS, managed under a standardized treatment protocol. We studied 127 male and 196 female patients with a mean age of 41±14 (range 18–83). All patients, except two, received ribavirin and steroid combination therapy. In 115 (36%) patients, the course of disease was limited. Pneumonitis progressed rapidly in the remaining patients. Sixty-seven (21%) patients required intensive care, and 42 (13%) required ventilator support. Advanced age, high admission neutrophil count, and high initial lactate dehydrogenase level were independent correlates of an adverse clinical outcome. SARS-associated coronavirus caused severe illnesses in most patients, despite early treatment with ribavirin and steroid. This study has identified three independent pretreatment prognostic correlates. KW - severe acute respiratory syndrome KW - clinical outcome KW - ribavirin KW - steroid KW - Hong Kong KW - China DO - 10.3201/eid0909.030362 UR - https://wwwnc.cdc.gov/eid/article/9/9/03-0362_article ER - End of Reference