Volume 10, Number 9—September 2004
Research
Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus
Robert B. Tesh*
, Douglas M. Watts*, Elena Sbrana*, Marina Siirin*, Vsevolod L. Popov*, and Shu-Yuan Xiao*
, Douglas M. Watts*, Elena Sbrana*, Marina Siirin*, Vsevolod L. Popov*, and Shu-Yuan Xiao*
Table 1
Results of virus titrations performed on blood (B) and throat swab (TS) samples from monkeypox virus–infected ground squirrelsa
| Animal no.b | Sample | Day after infection |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ||
| 11 | B | 0.7c | 0 | 1.4 | 2.9 | 4.0 | D | |||
| TS | NT | 0 | 0 | 3.1 | 5.3 | |||||
| 12 | B | 0 | 0 | 1.0 | 2.9 | 3.8 | 4.8 | D | ||
| TS | NT | 0 | 0 | 2.2 | 3.9 | 5.8 | ||||
| 13 | B | 0 | 0 | 1.2 | 3.2 | 4.2 | D | |||
| TS | NT | 0 | 0 | 3.9 | 5.8 | |||||
| 14 | B | 0 | 0 | 0.7 | 2.5 | 3.9 | D | |||
| TS | NT | 0 | 0 | 2.9 | 5.2 | |||||
| 15 | B | 0 | 0 | 0.7 | 3.0 | 3.9 | D | |||
| TS | NT | 0 | 0 | 2.5 | 6.0 | |||||
| 16 | B | 0 | 0 | 0 | 0 | 1.6 | 2.1 | 4.2 | D | |
| TS | NT | 0 | 0 | 1.7 | 3.7 | 4.6 | 5.3 | |||
| 17 | B | 0 | 0 | 0 | 0.7 | 2.1 | 2.7 | 5.0 | NT | D |
| TS | NT | 0 | 1.7 | 2.2 | 4.0 | 4.9 | 5.7 | 6.2 | ||
| 18 | B | 0 | 0 | 0 | 0 | 2.0 | 2.5 | 4.3 | D | |
| TS | NT | 0 | 1.0 | 1.9 | 2.9 | 3.5 | 4.6 | |||
| 19 | B | 0 | 0 | 0 | 0 | 0 | 1.9 | 4.7 | 4.2 | D |
| TS | NT | 1.8 | 2.3 | 3.0 | 3.9 | 4.0 | 5.4 | 4.9 | ||
| 20 | B | 0 | 0 | 0 | 0 | 1.0 | 2.5 | 5.1 | 4.8 | D |
| TS | NT | 2.5 | 1.7 | 2.5 | 3.7 | 3.9 | 3.7 | 5.4 | ||
aNT, not tested; D, animal dead.
bAnimals 11–15 were infected intraperitoneally; animals 16–20 were infected intranasally.
cVirus titer expressed as log10 PFU/mL of sample. Values <100.7 were beyond the sensitivity of the assay and were marked as zero.
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