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Volume 13, Number 2—February 2007
Synopsis

Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections

Janie Parrino*, Richard S. Hotchkiss†, and Mike Bray*Comments to Author 
Author affiliations: *National Institutes of Health, Bethesda, Maryland, USA; †Washington University School of Medicine, Saint Louis, Missouri, USA;

Main Article

Table 1

Distinguishing features of apoptosis and necrosis

FeatureApoptosisNecrosis
General description
Genetically programmed, orderly process of cell death
Accidental cell death caused by acute injury or other exogenous effect
Membrane integrity
Preserved until late in cell breakdown process
Early loss results in cell and organelle swelling and rupture
Chromosomal DNA
Cleavage at nucleosomes produces ladder pattern on an agarose gel
Random fragmentation produces smear pattern
Inflammatory responseNone; products have antiinflammatory effectRelease of intracellular contents causes acute inflammatory response

Main Article

Page created: June 29, 2010
Page updated: June 29, 2010
Page reviewed: June 29, 2010
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