Volume 13, Number 8—August 2007
Research
Risk Factors for Colonization with Extended-Spectrum β-Lactamase–producing Bacteria and Intensive Care Unit Admission
Anthony D. Harris*†
, Jessina C. McGregor*, Judith A. Johnson*†, Sandra M. Strauss*, Anita C. Moore*, Harold C. Standiford‡, Joan N. Hebden‡, and J. Glenn Morris*
, Jessina C. McGregor*, Judith A. Johnson*†, Sandra M. Strauss*, Anita C. Moore*, Harold C. Standiford‡, Joan N. Hebden‡, and J. Glenn Morris*
Table 1
Potential predictors of colonization by an ESBL-producing bacterium on ICU admission*
| Potential predictor | No. ESBL colonized (n = 117) | No. not ESBL colonized (n = 5,092) | p value† |
|---|---|---|---|
| Age, y (median, IQR) | 62 (49–71) | 56 (45–67) | <0.01 |
| CDS (median, IQR) | 8 (5–10) | 8 (5–10) | 0.20 |
| CDS-ID (median, IQR) | 3.21 (1.83–4.78) | 2.83 (1.83–3.40) | <0.01 |
| Sex, female, no. (%) | 59 (50) | 2,311 (45) | 0.30 |
| Antimicrobial drug exposures, no. (%)‡ | |||
| Quinolone | 18 (15) | 617 (12) | 0.32 |
| 1st-generation cephalosporin | 9 (8) | 559 (11) | 0.30 |
| 3rd-generation cephalosporin | 7 (6) | 293 (6) | 0.84 |
| Vancomycin | 34 (29) | 616 (12) | <0.01 |
| Aminoglycoside | 11 (9) | 366 (7) | 0.36 |
| Piperacillin-tazobactam | 50 (43) | 1,090 (21) | <0.01 |
| Cefepime | 9 (8) | 161 (3) | 0.01 |
| Imipenem | 11 (9) | 224 (4) | 0.02 |
*ESBL, extended-spectrum β-lactamase; ICU, intensive care unit; IQR, interquartile range; CDS, Chronic Disease Score; CDS-ID, infectious disease–specific CDS.
†Fisher exact test for dichotomous predictors and Wilcoxon test for continuous predictors.
‡Antimicrobial drug exposures that occurred during the index hospital admission but before ICU admission.
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