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Volume 5, Number 3—June 1999
Perspective

The Cost Effectiveness of Vaccinating against Lyme Disease

Martin I. MeltzerComments to Author , David T. Dennis, and Kathleen A. Orloski
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 2

Costs of treating one case of Lyme disease and the sequelae due to early and late disseminated disease

Item Cost/year
($) Length of treatment Total costsa
($)
Case resolved: no sequelae
Antibiotics 14
Office visits (2) 50
Laboratory tests 35
5 hrs lost work time 62
Total 161 2-3 wks 161
Sequelaeb due to early and 
 late disseminated disease
Cardiac-directc 5,445
Cardiac-indirectd 1,400
Cardiac-total 6,845 < 1 yr 6,845
Neurologic-directc 4,865
Neurologic-indirectd 2,100
Neurologic-total 6,965 11 yrs 61,243
Arthritic-directc 1,804
Arthritic-indirectd 2,100
Arthritic-total 3,904 11 yrs 34,354

aAll costs that occur over more than 1 year are discounted at a rate of 3% per year.
bSee text for description of the sequelae.
cDirect costs are for all medical costs and are derived from the 1-year charges reported by Magid et al. (29), inflated to 1996 dollars (factor of 1.528) (40), and then adjusted by a cost-to-charge ratio of 0.53 (43) (see text for details).
dIndirect costs are the valuation of lost productivity due to Lyme disease-related illness, with each day lost valued at $100. For cardiac-related sequelae, it was assumed that 14 workdays were lost, and for neurologic and arthritic-related sequelae, it was assumed that 21 workdays were lost each year.

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References
  1. Centers for Disease Control and Prevention. Lyme disease—United States, 1996. MMWR Morb Mortal Wkly Rep. 1997;46:5315.PubMedGoogle Scholar
  2. Berglund  J, Eitrem  R, Ornstein  K, Lindberg  A, Ringner  A, Elmrud  J, . An epidemiologic study of Lyme disease in southern Sweden. N Engl J Med. 1995;333:131924. DOIPubMedGoogle Scholar
  3. Strle  F, Stantic-Pavlinic  M. Lyme disease in Europe [letter, comment]. N Engl J Med. 1996;334:803. DOIPubMedGoogle Scholar
  4. Cartter  ML, Mshar  P, Hadler  JL. The epidemiology of Lyme disease in Connecticut. Conn Med. 1989;53:3203.PubMedGoogle Scholar
  5. Ginsberg  HS. Geographical spread of Ixodes dammini and Borrelia burgdorferi. In: Ginsberg HS, editor. Ecology and environmental management of Lyme disease. New Brunswick (NJ): Rutgers University Press; 1993. p. 63-82.
  6. White  DJ, Chong  HG, Benach  JL, Bosler  EM, Meldrum  SC, Means  RG, The geographic spread and temporal increase of the Lyme disease epidemic. JAMA. 1991;266:12306. DOIPubMedGoogle Scholar
  7. Dennis  DT. Lyme disease. Dermatol Clin. 1995;13:53751. DOIPubMedGoogle Scholar
  8. Schwartz  BS, Goldstein  MD, Childs  JE. Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers. Am J Public Health. 1993;83:17468. DOIPubMedGoogle Scholar
  9. Steere  AC, Sikand  VK, Meurice  F, Parenti  DL, Fikrig  E, Schoen  RT, Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. N Engl J Med. 1998;339:20915. DOIPubMedGoogle Scholar
  10. Sigal  HL, Zahradnik  JM, Levin  P, Patella  SJ, Bryant  G, Haselby  R, A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. N Engl J Med. 1998;339:21622. DOIPubMedGoogle Scholar
  11. Centers for Disease Control and Prevention. Notice to readers: availability of Lyme disease vaccine. MMWR Morb Mortal Wkly Rep. 1999;48:356, 43.PubMedGoogle Scholar
  12. Snider  DE, Holtgrave  DR, Duñet  DO. Decision analysis. In: Haddix AC, Teutsch SM, Shaffer PA, Duñet DO, editors. Prevention effectiveness: a guide to decision analysis and economic evaluation. New York: Oxford University Press; 1996. p. 27-46.
  13. Palisade Corporation. Guide to using @Risk (Windows version). Newfield (NY): Palisade Corporation; 1996.
  14. Dittus  RS, Roberts  SD, Wilson  JR. Quantifying uncertainty in medical decisions. J Am Coll Cardiol. 1989;14:23A8.PubMedGoogle Scholar
  15. Critchfield  GC, Willard  KE. Probabilistic analysis of decision trees using Monte Carlo simulation. Med Decis Making. 1986;6:8592. DOIPubMedGoogle Scholar
  16. Dobilet  P, Begg  CB, Weinstein  MC, Braun  P, McNeil  BJ. Probabilistic sensitivity analysis using Monte Carlo simulation: a practical approach. Med Decis Making. 1985;5:15777. DOIPubMedGoogle Scholar
  17. Telford  SR, Kantor  FS, Lobet  Y, Barthold  SW, Spielman  A, Flavell  RA, Efficacy of human Lyme disease vaccine formulations in a mouse model. J Infect Dis. 1995;171:136870.PubMedGoogle Scholar
  18. De Silva  AM, Telford  SR III, Brunet  LR, Barthold  SW, Fikrig  E. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J Exp Med. 1996;183:2715. DOIPubMedGoogle Scholar
  19. Straubinger  RK, Chang  YF, Jacobson  RH, Appel  MJG. Sera from OspA-vaccinated dogs, but not those from tick-infected dogs, inhibit in vitro growth of Borrelia burgdorferi. J Clin Microbiol. 1995;33:274551.PubMedGoogle Scholar
  20. Philipp  MT, Lobet  Y, Bohm  RP, Conway  MD, Dennis  VA, Desmons  P, Safety and immunogenicity of recombinant outer surface protein A (OspA) vaccine formulations in the rhesus monkey. Journal of Spirochetal Tickborne Disease 1996:67-79.
  21. Keller  D, Koster  FT, Marks  DH, Hosbach  P, Erdile  LF, Mays  JP. Safety and immunogenicity of a recombinant outer surface protein A Lyme Vaccine. JAMA. 1994;271:17648. DOIPubMedGoogle Scholar
  22. Schoen  RT, Meurice  F, Brunet  CM, Cretella  S, Krause  DS, Craft  JE, Safety and immunogenicity of an outer surface protein A vaccine in subjects with previous Lyme disease. J Infect Dis. 1995;172:13249.PubMedGoogle Scholar
  23. Padilla  ML, Callister  SM, Schell  RF, Bryant  GL, Jobe  DA, Loverich  SD, Characterization of the protective borreliacidal antibody response in humans and hamsters after vaccination with a Borrelia burgdorferi outer surface protein A vaccine. J Infect Dis. 1996;174:73946.PubMedGoogle Scholar
  24. Steere  AC. Lyme disease. N Engl J Med. 1989;321:58696.PubMedGoogle Scholar
  25. Massarotti  EM, Luger  SW, Rahn  DW, Messner  RP, Wong  JB, Johnson  RC, Treatment of early Lyme disease. Am J Med. 1992;92:396403. DOIPubMedGoogle Scholar
  26. Luger  SW, Paparone  P, Wormser  GP, Nadelman  RB, Grunwaldt  E, Gomez  G, Comparison of cefuroxime axetil and doxycycline in treatment of patients with early Lyme disease associated with erythema migrans. Antimicrob Agents Chemother. 1995;39:6617.PubMedGoogle Scholar
  27. Dattwyler  RJ, Luft  BJ, Kunkel  MJ, Finkel  MF, Wormser  GP, Rush  TJ, Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. N Engl J Med. 1997;337:28994. DOIPubMedGoogle Scholar
  28. Steere  AC, Levin  RE, Molloy  PJ, Kalish  RA, Abraham  JH, Liu  NY, Treatment of Lyme arthritis. Arthritis Rheum. 1994;37:87888. DOIPubMedGoogle Scholar
  29. Magid  D, Schwartz  B, Craft  J, Schwartz  JS. Prevention of Lyme disease after tick bites: a cost-effectiveness analysis. N Engl J Med. 1992;327:53441.PubMedGoogle Scholar
  30. Nichol  G, Dennis  DT, Steere  AC, Lightfood  R, Wells  G, Shea  B, Test-treatment strategies for patients suspected of having Lyme disease: a cost-effectiveness analysis. Ann Intern Med. 1998;128:3748.PubMedGoogle Scholar
  31. Lightfoot  RW, Luft  BJ, Rahn  DW, Steere  AC, Sigal  LH, Zoschke  DC, Empiric parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serological result for Lyme disease. Ann Intern Med. 1993;119:5039.PubMedGoogle Scholar
  32. Shadick  NA, Phillips  CB, Logigian  EL, Steere  AC, Kaplan  RF, Berardi  VP, The long-term clinical outcomes of Lyme disease. Ann Intern Med. 1994;121:5607.PubMedGoogle Scholar
  33. Alpert  B, Esin  J, Sivak  SL, Wormser  GP. Incidence and prevalence of Lyme disease in a suburban Westchester County community. N Y State J Med. 1992;92:58.PubMedGoogle Scholar
  34. Steere  AC, Taylor  E, Wilson  ML, Levine  JF, Spielman  A. Longitudinal assessment of the clinical and epidemiological features of Lyme disease in a defined population. J Infect Dis. 1986;154:295300.PubMedGoogle Scholar
  35. Kaslow  RA, Samples  CL, Simon  DG, Lewis  JN. Occurrence of erythema chronicum migrans and Lyme disease among children in two noncontiguous Connecticut counties. Arthritis Rheum. 1981;24:15126. DOIPubMedGoogle Scholar
  36. Hanrahan  JP, Benach  JL, Coleman  JL, Bosler  EM, Morse  DL, Cameron  DJ, Incidence and cumulative frequency of endemic Lyme disease in a community. J Infect Dis. 1984;150:48995.PubMedGoogle Scholar
  37. Lastavica  CC, Wilson  ML, Berardi  VP, Spielman  A, Deblinger  RD. Rapid emergence of a focal epidemic of Lyme disease in costal Massachusetts. N Engl J Med. 1989;320:1337.PubMedGoogle Scholar
  38. Maes  E, Lecomte  P, Ray  N. A cost-of-illness study of Lyme disease in the United States. Clin Ther. 1998;20:9931008. DOIPubMedGoogle Scholar
  39. Evans  M, Hastings  N, Peacock  B. Statistical distributions. 2nd ed. New York: John Wiley; 1993.
  40. Statistical abstract of the United States. 117th ed. Washington: U.S. Bureau of the Census; 1997.
  41. Meltzer  MI, Teutsch  SM. Setting priorities for health needs, managing resources. In: Teutsch SM, Stroup DF, editors. Quantitative solutions to public health problems. New York: Oxford University Press; 1998. p. 123-49.
  42. Haddix  AC, Shaffer  PA. Cost-effectiveness analysis. In: Haddix AC, Teutsch SM, Shaffer PA, Duñet DO, editors. Prevention effectiveness: a guide to decision analysis and economic evaluation. New York: Oxford University Press; 1996. p. 103-29.
  43. The Federal Register. Vol 61; no. 170; 1996 Aug 30; 46301-2.
  44. Productivity loss tables [Appendix I]. In: Haddix AC, Teutsch SM, Shaffer PA, Duñet DO, editors. Prevention effectiveness: a guide to decision analysis and economic evaluation. New York; Oxford University Press; 1996. p. 187-92.
  45. Fix  AD, Strickland  T, Grant  J. Tick bites and Lyme disease in an endemic setting. JAMA. 1998;279:20610. DOIPubMedGoogle Scholar
  46. Centers for Disease Control and Prevention. Lyme disease—United States, 1996. MMWR Morb Mortal Wkly Rep. 1997;46:5315.PubMedGoogle Scholar
  47. Coyle  BS, Strickland  GT, Liang  YY, Peña  C, McCarter  R, Israel  E. The public health impact of Lyme disease in Maryland. J Infect Dis. 1996;173:12602.PubMedGoogle Scholar
  48. Meek  JL, Roberts  CL, Smith  EV, Cartter  ML. Underreporting of Lyme disease by Connecticut physicians, 1992. J Public Health Manag Pract. 1996;2:615.PubMedGoogle Scholar
  49. Centers for Disease Control and Prevention. Prevention of Lyme disease through active immunization: recommendations of the Advisory Committee on Immunization practices (ACIP). MMWR Morb Mortal Wkly Rep. 1999. In press.
  50. Stratton  KR, Durch  JS, Lawrence  RS, eds. Vaccines for the 21st century: a tool for decision making. Washington: National Academy Press. In press 1999.

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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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