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Volume 6, Number 2—April 2000
Dispatch

Sin Nombre Virus (SNV) Ig Isotype Antibody Response during Acute and Convalescent Phases of Hantavirus Pulmonary Syndrome

Pavel Bostik*, Jorn Winter*†, Thomas G. Ksiazek†, Pierre E. Rollin†, Francois Villinger*, Sherif R. Zaki†, C.J. Peters†, and Aftab A. Ansari*Comments to Author 
Author affiliations: *Emory University School of Medicine, Atlanta, Georgia, USA; and †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table

Total Ig concentrations and specific Sin Nombre virus Ig titers in sera from patients with hantavirus pulmonary syndrome

Patienta Daysb IgM IgG1 IgG2 IgG3 IgG4 IgA Total IgM [mg/dl] Total IgG [mg/dl] Total IgA [mg/dl] Phase
7(d)c 1 25,600 400 0 1,600 0 25,600 264 1,000 336 Acute
8(d) 1 1,600 0 0 100 0 0 559 <333 <67 Acute
9(d) 1 25,600 400 0 6,400 0 102,400 295 802 <40 Acute
6.1 2 102,400 6,400 100 25,600 0 25,600 280 1,590 492 Acute
10(d) 2 25,600 100 0 400 0 0 ndd 4,840 234 Acute
5.1 2 25,600 100 0 1,600 0 409,600 1,080 176 342 Acute
21.1 4 102,400 100 6,400 409,600 0 0 409,600 nd nd Acute
23.1 7 25,600 100 100 400 0 25,600 nd nd nd Acute
1.1 7 1,600 400 100 6,400 0 400 142 401 108 Acute
11(d) 7 102,400 100 0 400 0 6,400 nd nd nd Acute
23.2 8 25,600 0 0 100 0 0 nd nd nd Acute
12(d) 8 6,400 0 0 0 0 0 108 <381 <67 Acute
4.3 10 6,400 0 0 1,600 0 25,600 nd nd nd Early conv.e
2.1 12 25,600 6,400 1,600 25,600 0 409,600 225 508 125 Early conv.
21.2 13 102,400 100 6,400 409,600 100 409,600 nd nd nd Early conv.
23.3 13 6,400 0 0 100 0 100 nd nd nd Early conv.
3.1 16 6,400 6,400 100 6,400 0 0 322 1,170 290 Early conv.
1.2 21 25,600 6,400 400 25,600 0 0 nd nd nd Early conv.
4.1 24 1,600 0 0 6,400 0 6,400 nd nd nd Early conv.
13 24 0 6,400 0 102,400 0 102,400 nd nd nd Early conv.
14 30 1,600 0 0 1,600 0 100 nd nd nd Early conv.
15 34 0 100 0 6,400 0 0 201 1,400 263 Late conv.
3.2 35 0 6,400 0 6,400 0 0 176 2,110 221 Late conv.
4.2 59 0 0 0 1,600 0 1,600 144 1,310 95 Late conv.
2.2 66 0 1,600 100 6,400 0 0 126 1,140 140 Late conv.
16 66 0 100 0 25,600 0 0 69 977 82 Late conv.
20.2 67 0 400 100 6,400 0 100 nd nd nd Late conv.
6.2 67 25,600 6,400 0 102,400 0 100 219 1,700 403 Late conv.
17.1 92 0 100 0 102,400 0 0 107 1,000 162 Late conv.
5.2 145 0 100 0 1,600 0 0 78 1,260 288 Late conv.
18 330 0 100 0 25,600 0 0 nd nd nd Late conv.
17.2 330 0 100 0 6,400 0 0 nd nd nd Late conv.
19 547 0 100 0 400 0 0 nd nd nd Late conv.

aDecimal values indicate sequential samples from one patient.
bDays after patient reported to hospital.
c(d) = patient died.
dnd = not done.
econv. = convalescent.

Main Article

Page created: December 16, 2010
Page updated: December 16, 2010
Page reviewed: December 16, 2010
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