Volume 8, Number 11—November 2002
THEME ISSUE
Tuberculosis Genotyping
Tuberculosis Genotyping Network, United States
Identifying the Sources of Tuberculosis in Young Children: A Multistate Investigation
Sumi J. Sun*
, Diane E. Bennett†, Jennifer Flood*, Ann M. Loeffler*, Steve Kammerer†, and Barbara A. Ellis†
, Diane E. Bennett†, Jennifer Flood*, Ann M. Loeffler*, Steve Kammerer†, and Barbara A. Ellis†
Table 1
Factors associated with identifying source patients for culture-confirmed tuberculosis in children <5 years of agea
| Characteristics | Suspected sources identified n=57 (%) | No suspected source identified n=45 (%) | Relative risk (95% CI) | p value | ||
|---|---|---|---|---|---|---|
| Age ≤2 yrsb | 44 | (77) | 20 | (45) | 1.96 (1.23 to 3.12) | 0.001 |
| Female | 30 | (53) | 21 | (47) | NS | |
| Race/ethnicity | NS | |||||
| Black, non-Hispanic | 26 | (46) | 19 | (42) | ||
| Hispanic | 23 | (40) | 12 | (27) | ||
| Asian | 5 | (9) | 11 | (24) | ||
| White, non-Hispanic | 1 | (2) | 3 | (7) | ||
| Native American or Alaskan Native | 2 | (4) | 0 | (0) | ||
| Foreign-bornc | 1 | (2) | 7 | (16) | 0.21 (0.03 to 1.31) | 0.02 |
| Type of disease | NS | |||||
| Pulmonary only | 40 | (70) | 30 | (67) | ||
| Extrapulmonary only | 5 | (9) | 8 | (18) | ||
| Pulmonary and extrapulmonary | 12 | (21) | 7 | (16) | ||
| Provider typed | NS | |||||
| Health department | 17 | (31) | 10 | (23) | ||
| Private provider | 18 | (33) | 21 | (49) | ||
| Both | 20 | (36) | 12 | (28) | ||
| Directly observed therapye | 46 | (85) | 28 | (68) | NS | |
| Drug-resistant isolatef | 6 | (11) | 8 | (16) | NS | |
aNS, not significant; CI, confidence interval.
bAge at start of treatment. Excludes one child whose date of treatment was unknown.
cExcludes one child whose birthplace was unknown.
dExcludes four children whose provider type was unknown.
eCompared to patients on self-administered therapy.
fDrug resistance on initial testing of isolate; resistance to at least one of the following: isoniazid, rifampin, ethambutol, pyrazinamide, streptomycin, and ethionamide. Testing results for one or more drugs could have been unknown or not done. Excludes two children for whom drug-susceptibility testing was not done.
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