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Volume 8, Number 11—November 2002
Dispatch

Genomewide Pattern of Synonymous Nucleotide Substitution in Two Complete Genomes of Mycobacterium tuberculosis

Austin L. Hughes*Comments to Author , Robert Friedman*, and Megan B. Murray†
Author affiliations: *University of South Carolina, Columbia, South Carolina, USA; †Harvard School of Public Health, Boston, Massachusetts, USA;

Main Article

Table 1

Estimatesa of the divergence time of the H37Rv and CDC1551 genotypes of Mycobacterium tuberculosis

Reference No. loci Synomymous substitutions/site/yr Divergence time (H37Rv and CDC1551)
11 67 4.7 ± 0.2 X 10-9 34,900 ± 2,300 b (33,500–36,400) c
12 128 4.4 X 10-9 37,300 ± 2,500 b

aBased on synonymous substitutions between Escherichia coli and Salmonella typhimurium, assumed to have diverged 100 million years ago (13,14).
bEstimates are shown ± standard error, based on standard error of mean pS.
cRange based on standard error of rate estimate.

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