Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 9, Number 1—January 2003
Perspective

Maintaining Fluoroquinolone Class Efficacy: Review of Influencing Factors

W. Michael Scheld*Comments to Author 
Author affiliation: *University of Virginia, School of Medicine, Charlottesville, Virginia, USA

Main Article

Table 5

Risk factors for infection or colonization with fluoroquinolone-resistant Streptococcus pneumoniaea

Factor Case patients
(n=27) Control
 patients
(n=54) Odds ratio
(95% CI) p value
Age (yr)b
72.5
(62.3–78.3)
75 (70–85)

0.01
Nursing home residence
14 (52%)
7 (13%)
7.2 (2.4 to 21.6)
< />
COPD
17 (63%)c
12 (22%)
5.9 (2.2 to 16.3)
0.001
Nosocomial
origin
18 (66%)
14 (26%)
5.7 (2.1 to 15.6)
0.001
Interval from day of admission to isolation of LRSP (days)b
7 (1–20)
1 (1–3)
-
< />
No. of prior
admissionsb
4 (2–7)
1 (0–3)
-
< />
Recent hospitalization
16 (59%)
13 (24%)
4.6 (1.7 to 12.3)
0.003
Multiple hospitalization
15 (56%)
12 (22%)
4.4 (1.6 to 11.8)
0.004
Previous exposure to antimicrobial agentsd




Fluoroquinolones
8 (30%)/14 (52%)
0 (0%)/5 (9%)
―/10.6 (3.2 to 34.7)
<0.001>< />
β-lactam antibiotics 24 (89%)/25 (93%) 20 (37%)/32 (59%): 14.7 (3.9 to 55.4)/8.6 (1.8 to 40) <0.001>

aCI, confidence interval; COPD, chronic obstructive pulmonary disease; LRSP, levofloxacin-resistant S. pneumoniae (73).
bMedian (interquartile range).
cColonization in 3 patients.
dExposure to antimicrobial therapy during the 6 weeks prior to hospitalization/12 months before hospitalization.

Main Article

Page created: December 07, 2010
Page updated: December 07, 2010
Page reviewed: December 07, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external