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Volume 9, Number 7—July 2003
Research

Amoeba-Resisting Bacteria and Ventilator-Associated Pneumonia

Bernard La Scola*, Ioanna Boyadjiev*†, Gilbert Greub*, Atieh Khamis*, Claude Martin†, and Didier Raoult*†Comments to Author 
Author affiliations: *Unité des Rickettsies, Marseille, France; †Hôpital Nord, Marseille, France

Main Article

Table 6

Clinical characteristics of patients with or without seroconversion to one of the amoeba-associated bacteriaa

Clinical characteristics Seroconversion
(N=12) No seroconversion
(N=18) p
value
Demographic data
Median age in y (IQR) 35 (25–43) 24 (21–52) 0.85
Male (%) 10 (83.3) 15 (83.3) 1
Risk and potential confounding factors
Underlying disease (%) 2 (16.6) 3 (16.6) 1
Circulation injury (%) 9 (75) 14 (77.8) 1
Median APACHE IIa score (IQR) 21 (14–4) 23 (16–34) 0.12
Intubation in ICU (%) 8 (66.6) 7 (38.9) 0.26
Median hospitalization days (IQR) 25 (19–41) 17 (10–23) 0.094
Median intubation duration in days (IQR) 11 (7–20) 11 (7–20) 0.8
Median number of serum samples (IQR) 3 (3–5) 3 (2–4) 0.12
Clinical data
VAP (%) 10 (83.3) 7 (38.9) 0.026
Unexplained VAP (%) 6 (50) 2 (11.1) 0.034
Fever > 38.5 °C (%) 12 (100) 17 (84.4) 1
Unexplained fever (%) 7 (58.3) 11 (39.3) 0.27
SIRS (%) 12 (100) 11 (61.1) 0.024
Unexplained SIRS (%) 7 (58.3) 3 (14.3) 0.045
Death (%) 2 (16.7) 8 (44.4) 0.23
Paraclinical data
Leukocytes > 12 g/L (%) 12 (100) 14 (77.8) 0.13
Platelets > 500 g/L (%) 5 (41.7) 6 (33.3) 0.7
PCR detection of ARB in BAL samples(%) 2 (17) 0 0.15

aIQR, interquartile range; VAP, ventilator-associated pneumonia; SIRS, Systemic Inflammatory Response Syndrome; APACHE II, Acute Physiology and Chronic Health Evaluation II; PCR, polymerase chain reaction; ARB, angiotensin receptor blockers; BAL, bronchoalveolar lavage samples; bold p values are those that are significant (<0.05).

Main Article

Page created: December 22, 2010
Page updated: December 22, 2010
Page reviewed: December 22, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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