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Volume 13, Number 5—May 2007
Dispatch

Chikungunya Virus in US Travelers Returning from India, 2006

Robert S. Lanciotti*Comments to Author , Olga L. Kosoy*, Janeen J. Laven*, Amanda J. Panella*, Jason O. Velez*, Amy J. Lambert*, and Grant L. Campbell*

Author affiliation: *Centers for Disease Control and Prevention, Fort Collins, Colorado, USA

Main Article

Table 1

Diagnostic test results for 35 travelers infected with chikungunya virus (CHIKV), 2006*

Sample IgM ELISA† IgG ELISA† PRNT‡ Virus isolation
(Vero cells) RT-PCR§ Viremia, PFU/mL¶ Days from onset of illness
to collection State of US
residence Return date, 2006
1
17.7
3.2
640


NA
0
NJ
10/12
2
1.7
1.7
<10

+
104.0
1
CA
Before 11/28
3
1.2
1.1
ND
+
+
104.1
1
IL
9/29
4
1.8
NS
ND
+
+
106.8
2
CA
Before 9/16
5
1.2
0.76
ND
+
+
105.1
2
MA
9/10
6
1.8
1.6
<10
+
+
106.0
3
PA
Before 8/20
7
1.6
1.2
ND
+
+
105.3
3
CA
10/2
8
NS
1.4
ND

+
103.9
4
WI
10/9
9
22.0
4.3
5,120


NA
4
CA
Before 10/6
10
1.1
0.95
<10

+
104.5
6
CA
Before 8/13
11
7.4
0.96
40


NA
7
CA
Before 9/23
12
15.0
0.60
320


NA
8
CT
Before 7/6
13
26.2
1.2
160
ND

NA
8
DC
Before 10/16
14
12.9
5.8
1,80
ND

NA
10
CA
Before 9/22
15
38.8
2.3
2,560
ND
ND
NA
19
CT
Before 7/6
16
12.7
1.5
640
ND

NA
20
IL
8/23
17
16.9
4.8
640
ND

NA
30
IL
6/25
18
8.3
3.7
640
ND
ND
NA
31
HI
Before 8/2
19
6.6
1.5
640
ND

NA
31
CA
Before 8/13
20
2.6
6.8
320
ND

NA
34
MD
Before 3/20
21
5.0
NS
640
ND

NA
34
IL
Before 9/22
22
15.1
4.1
1,280
ND

NA
38
CA
Before 10/2
23
4.3
5.9
2,560
ND

NA
42
PA
Before 8/20
24
5.6
NS
320
ND

NA
43
Unknown
Unknown
25
3.1
3.7
640
ND

NA
44
IL
Before 9/12
26
26.6
13.4
5,120
ND
ND
NA
48
SC
6/24
27
30.7
6.6
5,120
ND

NA
61
CA
Before 10/26
28
6.1
11.4
2,560
ND

NA
62
CT
Before 10/3
29
9.4
16.0
640
ND

NA
63
CA
8/23
30
7.5
8.4
1,280
ND

NA
71
MN
6/8
31
5.3
5.8
640
ND

NA
71
MN
6/8
32
3.7
16.1
320
ND

NA
75
LA
Before 3/30
33
9.8
10.1
2,560
ND

NA
92
IL
7/9
34
7.5
3.1
160
ND

NA
101
PA
Before 10/13
35 24.6 11.9 20,480 ND NA Unknown IL Before 11/08

*IgM, immunoglobulin M; PRNT, plaque reduction neutralization test; RT-PCR, reverse transcription–PCR; NA, not applicable; ND, not done
(sampled depleted); NS, nonspecific reaction in ELISA.
†Values are patient sample optical densities divided by a negative control optical density; values >3 are positive.
‡Values are 90% plaque reduction neutralization titers.
§Real-time, fluorescence-based assay for detecting CHIKV RNA; positive samples had crossing threshold values <37 with both primer sets.
¶Estimated CHIKV PFU/mL by real-time RT-PCR using a standard curve generated with plaque-titrated/calibrated CHIKV standards.

Main Article

Page created: June 24, 2010
Page updated: June 24, 2010
Page reviewed: June 24, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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