Volume 8, Number 3—March 2002
Research
Immunization with Heterologous Flaviviruses Protective Against Fatal West Nile Encephalitis
Robert B. Tesh
, Amelia P.A. Travassos da Rosa, Hilda Guzman, Tais P. Araujo, and Shu-Yuan Xiao
, Amelia P.A. Travassos da Rosa, Hilda Guzman, Tais P. Araujo, and Shu-Yuan Xiao
Table 1
Pattern of viremia and hemagglutination inhibition (HI) antibody response in 10 adult Flavivirus-naïve (control) hamsters, following intraperitoneal inoculation of 104 TCID50 of West Nile virus (WNV)
| Animal No. | Day postinoculation | |||||
|---|---|---|---|---|---|---|
| D-1 | D-2 | D-3 | D-4 | D-5 | D-6 | |
| 8001 | 4.3a(0) | 5.0 (0) | 5.0 (0) | 3.3 (0) | 1.0 (1:80) | 1.0 (1:320) |
| 8002 | 4.7 (0) | 5.5 (0) | 5.2 (0) | 3.5 (0) | 2.5 (1:40) | 0 (1:320) |
| 8003 | 5.3 (0) | 5.3 (0) | 5.0 (0) | 3.5 (0) | 2.5 (1:40) | 0 (1:320) |
| 8004 | 2.0 (0) | 5.0 (0) | 5.0 (0) | 4.3 (0) | 2.5 (1:40) | 1.0 (1:160) |
| 8005 | 4.0 (0) | 5.0 (0) | 5.5 (0) | 3.7 (0) | 1.7 (1:80) | 1.0 (1:320) |
| 8006 | 4.6 (0) | 5.2 (0) | 5.7 (0) | 4.3 (0) | 2.7 (1:80) | 0 (1:320) |
| 8007 | 4.3 (0) | 5.7 (0) | 4.6 (0) | 4.0 (0) | 2.0 (1:80) | 1.0 (1:320) |
| 8008 | 4.2 (0) | 5.8 (0) | 4.8 (0) | 1.8 (0) | 2.0 (1:80) | 0 (1:320) |
| 8009 | 5.2 (0) | 5.2 (0) | 5.0 (0) | 3.2 (0) | 2.8 (1:80) | 0 (1:320) |
| 8010 | 4.7 (0) | 4.7 (0) | 5.5 (0) | 3.5 (0) | 1.8 (1:80) | 0.7 (1:320) |
| Mean | 4.3 | 5.2 | 5.1 | 3.5 | 2.1 | 0.5 |
| SD | 0.92 | 0.34 | 0.34 | 0.71 | 0.54 | 0.50 |
aWNV titer expressed as log10 TCID50/mL of blood. 0 <0.7. (HI antibody titer; 0 <1:20)
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