Volume 10, Number 10—October 2004
Research
Molecular Evidence of Interhuman Transmission of Pneumocystis Pneumonia among Renal Transplant Recipients Hospitalized with HIV-Infected Patients
Meja Rabodonirina*1, Philippe Vanhems†, Sandrine Couray-Targe‡, René-Pierre Gillibert†, Christell Ganne‡, Nathalie Nizard†, Cyrille Colin‡, Jacques Fabry†, Jean-Louis Touraine§, Guy van Melle¶, Aimable Nahimana¶, Patrick Francioli¶1, and Philippe M. Hauser¶1
Table
Cases with Pneumocystis jirovecii pneumonia (PCP) and potential encounters 3 weeks to 3 months before their PCP episode with other patients with active PCP
| No. of encounters with patients with active PCP | No. patients with active PCP encountered |
Presumptive nosocomial PCPb | |||||
|---|---|---|---|---|---|---|---|
| Date of PCP | Underlying diseasea | P. jirovecii PCR-SSCP type | CD4 counts/mm3 | Total | With same P. jirovecii type | ||
| 1/10/94 | RTR | 1 and 6 | –c | 10 | 1 | 0 | No |
| 1/11/94 | RTR | 23 | – | 20 | 1 | 0 | No |
| 11/5/94 | RTR | Undetermined | – | 5 | 1 | 0 | No |
| 12/6/94 | HIV | 6 | 0 | 2 | 2 | 0 | No |
| 12/6/94 | RTR | 1 | – | 5 | 3 | 1 | Yes |
| 12/13/94 | HIV | 6 and 7 | 0 | 10 | 1 | 0 | No |
| 1/31/95 | HIV | 13 and 26 | 67 | 1 | 1 | 0 | No |
| 9/20/95 | HIV | 1 | 4 | 16 | 2 | 0 | No |
| 10/20/95 | HIV | 1 | 18 | 1 | 1 | 0 | No |
| 12/28/95 | RTR | 1 | – | 9 | 1 | 1 | Yes |
| 2/22/96 | RTR | 1 | – | 14 | 3 | 2 | Yes |
| 2/28/96 | HIV | 1 | 0 | 14 | 2 | 1 | Yes |
| 5/22/96 | RTR | 1 | – | 8 | 7 | 1 | Yes |
| 5/23/96 | RTR | 1 | – | 3 | 3 | 1 | Yes |
| Total | 8 RTRs, 6 HIV | 118 | 5 RTR, 1 HIV | ||||
aPCR, polymerase chain reaction; RTR, renal transplant recipient; SSCP, single-strand conformation polymorphism.
bNosocomial PCP was defined as PCP episode with exposure to one or several source patients infected with the same P. jirovecii type 3–12 weeks before the diagnosis.
cData not available.
1M. Rabodonirina, P. Francioli, and P.M. Hauser contributed equally to the work.
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