Volume 12, Number 1—January 2006
THEME ISSUE
Influenza
Prevention
Vaccines for Pandemic Influenza
Catherine J. Luke* and Kanta Subbarao*
Table 4
Preclinical testing to be performed on live attenuated pandemic influenza vaccine candidates
| In vitro testing | In vivo testing |
|---|---|
| Confirmation of virus genome sequence Trypsin-dependent replication in cell culture Confirmation of phenotype associated with the vaccine donor virus, e.g., temperature sensitivity, cold adaptation | Intravenous pathogenicity test in chickens Attenuation (restricted replication) in rodent or ferret model Immunogenicity in rodent or ferret model Protective efficacy in rodent model |
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