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Volume 12, Number 9—September 2006

Differentiation of Tuberculosis Strains in a Population with Mainly Beijing-family Strains

Vladyslav Nikolayevskyy*, Krishna Gopaul*, Yanina Balabanova*†, Timothy Brown*, Ivan Fedorin†, and Francis Drobniewski*Comments to Author 
Author affiliations: *Barts and the London School of Medicine, University of London, London, United Kingdom; †Samara Regional Tuberculosis Service, Samara, Russia

Main Article

Table 4

Frequency of MIRU-ETR alleles and allelic diversity at each locus for Beijing strains only*

Locus No. repeats
0 1 2 3 4 5 6 7 8 9
MIRU 2 0 0 127 1 0 0 1 0 0 0 0.031 3
MIRU 4 0 0 126 3 0 0 0 0 0 0 0.046 2
MIRU 10 0 2 1 126 0 0 0 0 0 0 0.046 3
MIRU 16 0 1 0 128 0 0 0 0 0 0 0.016 2
MIRU 20 0 0 129 0 0 0 0 0 0 0 0 1
MIRU 23 0 0 0 0 0 128 0 1 0 0 0.016 2
MIRU 24 0 129 0 0 0 0 0 0 0 0 0 1
MIRU 26 0 0 0 2 1 89 0 37 0 0 0.445 4
MIRU 27 0 0 0 129 0 0 0 0 0 0 0 1
MIRU 31 0 1 0 1 6 117 4 0 0 0 0.176 5
MIRU 39 0 0 1 128 0 0 0 0 0 0 0.016 2
MIRU 40 0 0 1 127 0 1 0 0 0 0 0.031 3
ETR-A 0 0 0 3 126 0 0 0 0 0 0.046 2
ETR-B 0 0 129 0 0 0 0 0 0 0 0 1
ETR-C 0 1 0 128 0 0 0 0 0 0 0.016 2

*N = 129; MIRU, mycobacterial interspersed repetitive units; ETR, exact tandem repeats; HGDI, Hunter-Gaston diversity index; AV, allelic variants.
Boldface loci showed at least moderate discriminative power as defined by Sola et al. (23) and were the most promising loci. Other loci provided poor discrimination or were monomorphic.

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