Volume 15, Number 1—January 2009
Threat of Dengue to Blood Safety in Dengue-Endemic Countries
|Virus||Route of transmission||Comment||References|
|Dengue||Percutaneous||Several healthcare workers were infected after needlestick injuries during care of returned travelers who had diagnoses of dengue.||(8,10–13)|
|Mucocutaneous||A healthcare worker became infected with dengue 3 virus after being splashed in the face by blood from a febrile traveler who had a diagnosis of dengue.||(7,14)|
|Blood transfusion||A 17-year-old man from Hong Kong, Special Administrative Region, People’s Republic of China, donated blood in July 2002, from which erythrocytes were transfused to a 72-year-old woman, in whom febrile illness consistent with dengue fever developed 3 d later.||(15)|
|Bone marrow transplant||A 6-year-old child from Puerto Rico became infected with dengue 4 virus from a bone marrow transplant and died.||(16)|
||Dengue hemorrhagic fever developed after a living donor renal transplant.
||A laboratory technician acquired yellow fever after obtaining blood and performing a blood count on a yellow fever patient; he died subsequently. Yellow fever was transmitted to at least 30 other scientists and laboratory workers after contact with mouse or monkey blood or tissues or handling infected animals.
|West Nile||Percutaneous||Virus was transmitted to 2 microbiologists by laceration or needlestick injuries in laboratory.||(21)|
|Transfusion||Virus was transmitted to numerous recipients of blood products.||(22,23)|
|Organ transplant||Virus was transmitted to transplant recipients from kidneys, liver, and heart of an infected donor.||(24)|
|Hemodialysis||Virus infection in a cluster of 3 hemodialysis patients suggested transmission through a common dialysis machine.||(25)|
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- Rigau-Perez JG, Vorndam AV, Clark GG. The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994–1995. Am J Trop Med Hyg. 2001;64:67–74.
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- Centers for Disease Control and Prevention. Possible dialysis-related West Nile virus transmission—Georgia, 2003. MMWR Morb Mortal Wkly Rep. 2004;53:738–9.
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- Linnen JB, Collins A, Cary C, Kolk JDP. Detection of dengue virus RNA in blood donors from Honduras and Brazil with a prototype transcription-mediated amplification assay. Annual Meeting of the American Association of Blood Banks; 2006 Oct 21–24: Miami. Abstracts. p. 11.
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