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Volume 16, Number 7—July 2010
Dispatch

Accumulation of L-type Bovine Prions in Peripheral Nerve Tissues

Yoshifumi IwamaruComments to Author , Morikazu Imamura, Yuichi Matsuura, Kentaro Masujin, Yoshihisa Shimizu, Yujing Shu, Megumi Kurachi, Kazuo Kasai, Yuichi Murayama, Shigeo Fukuda, Sadao Onoe, Ken’ichi Hagiwara, Yoshio Yamakawa, Tetsutaro Sata, Shirou Mohri, Hiroyuki Okada, and Takashi Yokoyama
Author affiliations: National Institute of Animal Health, Tsukuba, Ibaraki, Japan (Y. Iwamaru, M. Imamura, Y. Matsuura, K. Masujin, Y. Shimizu, Y. Shu, M. Kurachi, K. Kasai, Y. Murayama, S. Mohri, H. Okada, T. Yokoyama); Hokkaido Animal Research Center, Hokkaido, Japan (S. Fukuda, S. Onoe); National Institute of Infectious Diseases, Tokyo, Japan (K. Hagiwara, Y. Yamakawa, T. Sata)

Main Article

Table

Western blot detection of PrPres in tissue samples obtained from cattle intracerebrally challenged with BSE/JP24 prion*

Tissue samples Cattle identification codes
8515 (10 mpi) 498 (12 mpi) 528 (16 mpi) 1061 (16 mpi) 5566 (16 mpi)
Nerve tissues
Obex + + + + +
Spinal cord + + + + +
Cauda equina + + + + +
Optic nerve + + + + +
Pituitary gland + + + + +
Trigeminal ganglia + + + + +
Cranial cervical ganglia + + + + +
Stellate ganglia + + + + +
Vagosympathic trunk + + + + +
Cranial mesenteric ganglia + + + + +
Vagus nerve + + + + +
Facial nerve
Hypoglossal nerve
Phrenic nerve + + + +
Accessory nerve + + + +
Suprascapular nerve + + +
Brachial nerve plexus + + +
Median nerve + +
Radial nerve + +
Sciatic nerve + + + +
Tibial nerve + + + +
Adrenal gland

+
+
+
+
Lymphoid tissues
Spleen
Tonsil
Parotid lymph nodes
Lateral retropharyngeal lymph nodes
Mandibular lymph nodes
Brachiocephalic lymph node
Anterior cervical lymph node
Axillary lymph nodes
Superficial inguinal lymph nodes
Subiliac lymph nodes
Popliteal lymph nodes
Splenic lymph nodes
Hepatic lymph nodes
Internal iliac lymph nodes
External iliac lymph nodes
Mesenteric lymph nodes

*PrPres, prion protein resistant; BSE, bovine spongiform encephalopathy; mpi, months postinoculation; +, positive for PrPres; –, negative for PrPres.

Main Article

Page created: March 02, 2011
Page updated: March 02, 2011
Page reviewed: March 02, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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