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Volume 16, Number 7—July 2010

High Diversity and Ancient Common Ancestry of Lymphocytic Choriomeningitis Virus

Cesar G. Albariño1Comments to Author , Gustavo Palacios1, Marina L. Khristova, Bobbie R. Erickson, Serena A. Carroll, James A. Comer, Jeffrey Hui, Thomas Briese, Kirsten St. George, Thomas G. Ksiazek2, W. Ian Lipkin, and Stuart T. Nichol
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.G. Albariño, M.L. Khristova, B.R. Erickson, S.A. Carroll, J.A. Comer, T.G. Ksiazek, S.T. Nichol); Columbia University, New York, New York, USA (G. Palacios, J. Hui, T. Briese, W.I. Lipkin); New York State Department of Health, Albany, New York, USA (K. St. George)

Main Article

Table 1

Origins of lymphocytic choriomeningitis virus strains analyzed*

Strain (other names) Collection date (passage history) Associated case (sample source) GenBank accession no.
Massachusetts-2008 (811316, 200802972) Massachusetts, USA, 2008 Transplant case (human blood) FJ607022,† FJ607031†
Dandenong Former Yugoslavia, 2006 Transplant case (human liver) EU136039, EU136038
Rhode Island-2005 (810850, 200501927) Rhode Island, USA, 2005 Transplant case (hamster kidney) FJ607021,† FJ607030†
Ohio-2005(810896, 200504261) Ohio, USA, 2005 Transplant case (hamster kidney) FJ607026,† FJ607037†
Michigan-2005 (810885, 200504219) Michigan, USA, 2005 House rodent infestation (mouse spleen) FJ607023,† FJ607032†
California-2003 (810366, 200312154) California, USA, 2003 Congenital infection (human CSF) FJ607019,† FJ607028†
Wisconsin-2003 (810362, 200312181) Wisconsin, USA, 2003 Transplant case (human CSF) FJ607027,† FJ607038†
Lyles (810935, Georgia-1984) Georgia, USA, 1984 House rodent infestation (human CSF) FJ607020,† FJ607029†
Douglas-4707 (810938, NY-H938) New York, USA, 1947 (stock lyophilized in 1960; 1 passage in VE6 in 2005) Human CSF FJ607024,† FJ607035†
WHI-5107 (810906, NY-H906) New York, USA,1949 (stock lyophilized in 1950) Human CSF FJ607033†
WE-UBC-57135 (810940, NY-H940) New York, USA,1935 (7 passages in MB, plaque purified; stock lyophilized in 1960; 1 passage in VE6 in 2005) Human specimen FJ607025,† FJ607036†
WE-UBC-A337 (810909, NY-H909) New York, USA, 1935 (7 passages in MB, stock lyophilized in 1950) Human specimen FJ607034†
Bulgaria Bulgaria, 1956? (WRCEVA collection at UTMB) ? GQ862981,† GQ862982†
M1, M2 Austria, 2005 Infection of mouse colony (mouse spleen) AB261990, AB261991
LE France, 2006 Congenital infection (amniotic fluid) EF164923
Marseille France, 2004 House rodent infestation (mouse kidney) DQ286932, DQ286931
CH5692, CH5871 Germany, 1999; Germany, 2000 Infection of monkey colony (monkey spleen and serum) AY363903, AF325214, AF325215,
CHV1, CHV2, CHV3 Oklahoma, USA,1986 Infection of monkey colony (monkey liver) U10157, U10158, U10159
MX Slovakia, 1998 Persistently infected cell line EU195888, EU195889
Yale (Y) Connecticut, USA, 1977 Mouse DQ118959
WE New York, USA, 1935 First recognized aseptic meningitis by LCMV M22138, AF004519
Armstrong Missouri, USA, 1933 St. Louis encephalitis epidemics AY847351, M20869
CABN, GR01, SN05 Spain, 2004 Wild mice (mouse lungs) FJ895882, FJ895883, FJ895884

*CSF, cerebrospinal fluid; MB, mouse brains; WRCEVA, World Reference Center of Emerging Viruses and Arboviruses; UTMB, University of Texas Medical Branch; LCMV, lymphocytic choriomeningitis virus. ? represents the uncertainty of this virus origin.
†New sequences.

Main Article

1These authors contributed equally to this article.

2Current affiliation: University of Texas Medical Branch, Galveston, Texas, USA.

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