Figure 1. Histopathologic analysis of transgenic mouse expressing bovine prion protein (PrP) gene inoculated with bovine spongiform encephalopathy agent. Spongiform degeneration in the thalamus (A), adjacent section showing PrP immunopositivity (B). Panel A was stained with hematoxylin and eosin, panel B was immunostained with PrP antibody 6D11. Scale bars = 100 μm.