Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 17, Number 7—July 2011

Neurognathostomiasis, a Neglected Parasitosis of the Central Nervous System

Juri Katchanov, Kittisak Sawanyawisuth, Verajit Chotmongkol, and Yukifumi NawaComments to Author 
Author affiliations: Author affiliations: Mahidol University, Bangkok, Thailand (J. Katchanov, Y. Nawa); Khon Kaen University, Khon Kaen, Thailand (K. Sawanyawisuth, V. Chotmongkol)

Main Article

Table 3

Proposed diagnostic criteria for neurognathostomiasis*

Epidemiologic criteria
Travel or residence in the disease-endemic area
AND exposure to undercooked freshwater fish, frogs, poultry,
and shellfish
Clinical syndrome
Painful radiculomyelitis/radiculomyeloencephalitis
OR meningitis/meningoencephalitis
OR intracerebral hemorrhage
OR subarachnoid hemorrhage
Indirect evidence of CNS invasion
CSF studies: eosinophilic pleocytosis
OR neuroimaging: parenchymal hemorrhagic tracks (>3 mm)
Positive detection of reactivity against the 24-kDa component
of Gnathostoma spinigerum in immunoblot test†
Absence of reactivity against the 29–31-kDa components of
Angiostrongylus cantonensis in immunoblot test

*All criteria should be fullfiled for clinical diagnosis of neurognathostomiasis. CNS, central nervous system; CSF, cerebrospinal fluid.
†If negative, a follow-up examination 4 weeks later is recommended.

Main Article

Page created: August 16, 2011
Page updated: August 16, 2011
Page reviewed: August 16, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.