Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model
Nadine Mestre-Francés

, Simon Nicot, Sylvie Rouland, Anne-Gaëlle Biacabe, Isabelle Quadrio, Armand Perret-Liaudet, Thierry Baron, and Jean-Michel Verdier
Author affiliations: Institut National de la Santé et de la Recherche Médicale (INSERM) U710, Montpellier, France (N. Mestre-Francés, S. Rouland, J.-M. Verdier); Université Montpellier 2, Montpellier (N. Mestre-Francés, S. Rouland, J.-M. Verdier); École Pratique des Hautes Etudes, Paris, France (N. Mestre-Francés, S. Rouland, J.-M. Verdier); Agence Nationale de Sécurité Sanitaire, Lyon, France (S. Nicot, A.-G. Biacabe, T. Baron); Hopitaux Civils de Lyon, Lyon, France (I. Quadrio, A. Perret-Liaudet); Université Lyon 1, Lyon (I. Quadrio, A. Perret-Liaudet); INSERM U1028, Lyon (I. Quadrio, A. Perret-Liaudet); Centre National de la Recherche Scientifique, Lyon (I. Quadrio, A. Perret-Liaudet)
Main Article
Table
Experimental transmission of cattle-derived L-BSE agent to 12 mouse lemurs, by 2 routes of inoculation*
Inoculation route |
L-BSE dose, mg |
Inoculated animals
|
No. inoculated (no. alive) |
Age at inoculation |
Survival after inoculation, mo |
Positive for PrPd † |
Intracerebral |
5 |
4 |
1 y |
19; 19.5; 22; 22 |
4/4 |
Oral |
50 |
3 (1‡) |
2 mo or 2 y |
18‡; 32 |
2/2 |
Oral |
5 |
5 (2‡) |
2 mo or 2 y |
27; 33; 34 |
2/3 |
Main Article
Page created: December 22, 2011
Page updated: December 22, 2011
Page reviewed: December 22, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.