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Volume 18, Number 11—November 2012

Lack of Evidence for Zoonotic Transmission of Schmallenberg Virus

Chantal Reusken1Comments to Author , Cees van den Wijngaard1, Paul van Beek, Martin Beer, Ruth Bouwstra, Gert-Jan Godeke, Leslie Isken, Hans van den Kerkhof, Wilfrid van Pelt, Wim van der Poel, Johan Reimerink, Peter Schielen, Jonas Schmidt-Chanasit, Piet Vellema, Ankje de Vries, Inge Wouters, and Marion Koopmans
Author affiliations: National Institute for Public Health and the Environment, Bilthoven, the Netherlands (C. Reusken, C. van den Wijngaard, P. van Beek, G.-J. Godeke, L. Isken, H. van den Kerkhof, W. van Pelt, J. Reimerink, P. Schielen, A. de Vries, M. Koopmans); Friedrich-Loeffler-Institut, Insel Riems, Germany (M. Beer); Central Veterinary Institute of Wageningen University and Research Centre, Lelystad, the Netherlands (R. Bouwstra, W. van der Poel); Bernhard Nocht Institute for Tropical Medicine, Hamburg (J. Schmidt-Chanasit); Animal Health Service, Deventer, the Netherlands (P. Vellema); and Institute for Risk Assessment Sciences, Utrecht, the Netherlands (I. Wouters)

Main Article

Table 2

Evidence for zoonotic infection within the family Bunyaviridae, Orthobunyavirus genus, the Netherlands*

Serogroup, species Geographic distribution Reservoir Human infection Evidence Reported symptoms in humans Congenital disease in humans References

Oropouche virus

South America Humans, sloths, marmosets Yes Outbreaks Febrile illness, arthralgia, diarrhea NR (18,20)

Iquitos virus

South America Humans, unknown Yes Unexplained fever surveillance Febrile illness, arthralgia, diarrhea NR (21)

Akabane virus

Asia, Israel, Kenya, Australia Cattle, horses, sheep No No serology NR NR (22,23)

Shamonda virus

Africa Cattle No No serology NR NR (24,25)

Aino virus

Asia Cattle Possibly Serology Unknown Unknown (22,23,26)

Shuni virus

Africa Cattle, horses, sheep Possibly Virus isolation (one case) Fever, no hospital submission NR (2729)

Sathuperi virus

Asia, Africa Cattle Unknown Unknown Unknown Unknown (30)
California encephalitis

California encephalitis

North America Rodents, lagomorphs Yes Endemic, common Febrile illness, encephalitis NR (31)

La Crosse virus

North America Rodents, lagomorphs Yes Endemic common Febrile illness, encephalitis NR (31)

Tahyna virus

Europe, Asia, Africa Lagomorphs, rodents, hedgehogs Yes Serology, cases Febrile illness, respiratory symptoms
meningitis (mild) NR (32)

Inkoo virus

Northern Europe Lagomorphs Yes Surveillance febrile illness, CNS illness, Febrile illness, Meningitis (mild) NR (32)

Snowshoe hare virus

North America, Far-Eastern Europe Lagomorphs, rodents Yes Serology, case reports Febrile illness NR (32)

Batai virus

Europe, Asia, Africa Birds,pigs, horses, ruminants Yes Serology (rare) Febrile illness, affection NR (32)

Cache Valley virus

North America Deer, sheep, horses, cattle Yes 2 Case reports, serology Febrile illness, encephalitis Under discussion (3335)

Ngari virus

Africa Humans, unknown Yes Outbreaks, virus isolation Febrile illness, hemorragic fever NR (3638)

*NR, not reported; CNS, central nervous system.

Main Article

  1. Hoffmann  B, Scheuch  M, Hoper  D, Jungblut  R, Holsteg  M, Schirrmeier  H, Novel orthobunyavirus in cattle, Europe, 2011. Emerg Infect Dis. 2012;18:46972. DOIPubMedGoogle Scholar
  2. Muskens  J, Smolenaars  AJ, van der Poel  WH, Mars  MH, van Wuijckhuise  L, Holzhauer  M, Diarrhea and loss of production on Dutch dairy farms caused by the Schmallenberg virus [in Dutch]. Tijdschr Diergeneeskd. 2012;137:1125.PubMedGoogle Scholar
  3. van den Brom  R, Luttikholt  SJ, Lievaart-Peterson  K, Peperkamp  NH, Mars  MH, van der Poel  WH, Epizootic of ovine congenital malformations associated with Schmallenberg virus infection. Tijdschr Diergeneeskd. 2012;137:10611.PubMedGoogle Scholar
  4. European Food Safety Authority. Scientific report of EFSA. “Schmallenberg” virus: analysis of the epidemiological data and assessment of impact. EFSA Journal. 2012;10:2768–857 [cited 2012 Aug 22].
  5. Gariglinay  MM, Hoffmann  B, Dive  M, Sartelet  A, Bayrou  C, Cassart  D, Schmallenberg virus in calf born at term with porencephaly, Belgium. Emerg Infect Dis. 2012;18:10056.PubMedGoogle Scholar
  6. Bilk  S, Schulze  C, Fischer  M, Beer  M, Hlinak  A, Hoffmann  B, Organ distribution of Schmallenberg virus RNA in malformed newborns. Vet Microbiol. 2012;159:2368. DOIPubMedGoogle Scholar
  7. ProMED-Mail. Schmallenberg virus–Europe (45): Denmark, serological evidence. 2012 [cited 2012 Jun 16]., archive no. 20120605.1157269.
  8. Food and Product Safety Authority (nVWA). Aantallen meldingen Schmallenbergvirus per provincie. 2012 [cited 2012 Jun 16].
  9. Yanase  T, Kato  T, Aizawa  M, Shuto  Y, Shirafuji  H, Yamakawa  M, Genetic reassortment between Sathuperi and Shamonda viruses of the genus Orthobunyavirus in nature: implications for their genetic relationship to Schmallenberg virus. Arch Virol. 2012;157:16116. DOIPubMedGoogle Scholar
  10. Calisher  CH, editor. History, classification and taxonomy of viruses in the family Bunyaviridae. New York: Plenum Press; 1996.
  11. Kinney  RM, Calisher  CH. Antigenic relationships among Simbu serogroup (Bunyaviridae) viruses. Am J Trop Med Hyg. 1981;30:130718.PubMedGoogle Scholar
  12. Saeed  MF, Li  L, Wang  H, Weaver  SC, Barrett  AD. Phylogeny of the Simbu serogroup of the genus Bunyavirus. J Gen Virol. 2001;82:217381.PubMedGoogle Scholar
  13. Jöst  H, Bialonski  A, Schmetz  C, Günther  S, Becker  N, Schmidt-Chanasit  J. Isolation and phylogenetic analysis of Batai virus, Germany. Am J Trop Med Hyg. 2011;84:2413. DOIPubMedGoogle Scholar
  14. Bardos  V, Danielova  V. The Tahyna virus—a virus isolated from mosquitoes in Czechoslovakia. J Hyg Epidemiol Microbiol Immunol. 1959;3:26476.PubMedGoogle Scholar
  15. Brummer-Korvenkontio  M, Saikku  P, Korhonen  P, Ulmanen  I, Reunala  T, Karvonen  J. Arboviruses in Finland. IV. Isolation and characterization of Inkoo virus, a Finnish representative of the California group. Am J Trop Med Hyg. 1973;22:40413.PubMedGoogle Scholar
  16. Grimstad  PR, Barrett  CL, Humphrey  RL, Sinsko  MJ. Serologic evidence for widespread infection with La Crosse and St. Louis encephalitis viruses in the Indiana human population. Am J Epidemiol. 1984;119:91330.PubMedGoogle Scholar
  17. Azevedo  RS, Nunes  MR, Chiang  JO, Bensabath  G, Vasconcelos  HB, Pinto  AY, Reemergence of Oropouche fever, northern Brazil. Emerg Infect Dis. 2007;13:9125. DOIPubMedGoogle Scholar
  18. Vasconcelos  HB, Azevedo  RS, Casseb  SM, Nunes-Neto  JP, Chiang  JO, Cantuaria  PC, Oropouche fever epidemic in northern Brazil: epidemiology and molecular characterization of isolates. J Clin Virol. 2009;44:12933. DOIPubMedGoogle Scholar
  19. Kinney  RM. Bwamba and Pongola virus. In: The encyclopedia of arthropod-transmitted infections. Service MW, editor. Wallingford (UK): CAB International; 2001.
  20. Pinheiro  FP, Travassos da Rosa  AP, Travassos da Rosa  JF, Ishak  R, Freitas  RB, Gomes  ML, Oropouche virus. I. A review of clinical, epidemiological, and ecological findings. Am J Trop Med Hyg. 1981;30:14960.PubMedGoogle Scholar
  21. Aguilar  PV, Barrett  AD, Saeed  MF, Watts  DM, Russell  K, Guevara  C, Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. PLoS Negl Trop Dis. 2011;5:e1315. DOIPubMedGoogle Scholar
  22. Boughton  CR, Hawkes  RA, Naim  HM. Arbovirus infection in humans in NSW: seroprevalence and pathogenicity of certain Australian bunyaviruses. Aust N Z J Med. 1990;20:515. DOIPubMedGoogle Scholar
  23. Ali  H, Ali  AA, Atta  MS, Cepica  A. Common, emerging, vector-borne and infrequent abortogenic virus infections of cattle. Transbound Emerg Dis. 2012;59:1125. DOIPubMedGoogle Scholar
  24. Shamonda virus (SHAV); Arbocat virus ID 436. 2012 [cited 2012 Jun 13].
  25. Yanase  T, Maeda  K, Kato  T, Nyuta  S, Kamata  H, Yamakawa  M, The resurgence of Shamonda virus, an African Simbu group virus of the genus Orthobunyavirus, in Japan. Arch Virol. 2005;150:3619. DOIPubMedGoogle Scholar
  26. Fukuyoshi  S, Takehara  Y, Takahashi  K, Mori  R. The incidence of antibody to Aino virus in animals and humans in Fukuoka. Jpn J Med Sci Biol. 1981;34:413.PubMedGoogle Scholar
  27. Causey  OR, Kemp  GE, Causey  CE, Lee  VH. Isolations of Simbu-group viruses in Ibadan, Nigeria 1964–69, including the new types Sango, Shamonda, Sabo and Shuni. Ann Trop Med Parasitol. 1972;66:35762.PubMedGoogle Scholar
  28. Moore  DL, Causey  OR, Carey  DE, Reddy  S, Cooke  AR, Akinkugbe  FM, Arthropod-borne viral infections of man in Nigeria, 1964–1970. Ann Trop Med Parasitol. 1975;69:4964.PubMedGoogle Scholar
  29. van Eeden  C, Williams  JH, Gerdes  TG, van Wilpe  E, Viljoen  A, Swanepoel  R, Shuni virus as cause of neurologic disease in horses. Emerg Infect Dis. 2012;18:31821. DOIPubMedGoogle Scholar
  30. Yanase  T, Fukutomi  T, Yoshida  K, Kato  T, Ohashi  S, Yamakawa  M, The emergence in Japan of Sathuperi virus, a tropical Simbu serogroup virus of the genus Orthobunyavirus. Arch Virol. 2004;149:100713. DOIPubMedGoogle Scholar
  31. Calisher  CH. Medically important arboviruses of the United States and Canada. Clin Microbiol Rev. 1994;7:89116.PubMedGoogle Scholar
  32. Hubálek  Z. Mosquito-borne viruses in Europe. Parasitol Res. 2008;103(Suppl 1):S2943. DOIPubMedGoogle Scholar
  33. Elliott  RM. Emerging viruses: the Bunyaviridae. Mol Med. 1997;3:5727.PubMedGoogle Scholar
  34. Calisher  CH, Sever  JL. Are North American Bunyamwera serogroup viruses etiologic agents of human congenital defects of the central nervous system? Emerg Infect Dis. 1995;1:14751. DOIPubMedGoogle Scholar
  35. Campbell  GL, Mataczynski  JD, Reisdorf  ES, Powell  JW, Martin  DA, Lambert  AJ, Second human case of Cache Valley virus disease. Emerg Infect Dis. 2006;12:8546. DOIPubMedGoogle Scholar
  36. Bowen  MD, Trappier  SG, Sanchez  AJ, Meyer  RF, Goldsmith  CS, Zaki  SR, A reassortant bunyavirus isolated from acute hemorrhagic fever cases in Kenya and Somalia. Virology. 2001;291:18590. DOIPubMedGoogle Scholar
  37. Briese  T, Bird  B, Kapoor  V, Nichol  ST, Lipkin  WI. Batai and Ngari viruses: M segment reassortment and association with severe febrile disease outbreaks in East Africa. J Virol. 2006;80:562730. DOIPubMedGoogle Scholar
  38. Gerrard  SR, Li  L, Barrett  AD, Nichol  ST. Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa. J Virol. 2004;78:89226. DOIPubMedGoogle Scholar
  39. Saeed  MF, Wang  H, Suderman  M, Beasley  DW, Travassos da Rosa  A, Li  L, Jatobal virus is a reassortant containing the small RNA of Oropouche virus. Virus Res. 2001;77:2530. DOIPubMedGoogle Scholar
  40. Yanase  T, Aizawa  M, Kato  T, Yamakawa  M, Shirafuji  H, Tsuda  T. Genetic characterization of Aino and Peaton virus field isolates reveals a genetic reassortment between these viruses in nature. Virus Res. 2010;153:17. DOIPubMedGoogle Scholar

Main Article

1These authors contributed equally to this article.

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