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Volume 18, Number 9—September 2012
Letter

Measles and Secondary Hemophagocytic Lymphohistiocytosis

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To the Editor: We found interesting the article by Lupo et al. about a case of fatal measles in an immunocompetent 29-year-old woman (Fatal measles without rash in immunocompetent adult, France; http://dx.doi.org/10.3201/eid1803.111300). Perhaps, however, the possible diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH) should also have been considered in that setting.

HLH is a potentially fatal hyperinflammatory syndrome characterized by histiocyte proliferation and hemophagocytosis. HLH may be inherited (i.e., primary, familial, generally occurring in infants) or may occur at any age secondary to infection, malignancy, or rheumatologic disease. Secondary HLH is determined according to clinical criteria from the HLH Study Group of the Histiocyte Society, which require >5 of the following for a diagnosis: fever; splenomegaly; cytopenia (affecting >2 cell lineages); hypertriglyceridemia or hypofibrinogenemia; hemophagocytosis in the bone marrow, spleen, or lymph nodes; low or absent natural killer cell cytotoxicity; hyperferritinemia; and elevated levels of soluble CD25.

We conducted a PubMed search and found 5 articles that described 6 cases of HLH in patients with measles (15). Pneumonia was described in all of them (15), and central nervous system involvement was described in 3 (1,4). Four cases occurred in children, 3 of them immunocompetent (1,35). The 2 adults were an immunocompetent 18-year-old man who had acute respiratory distress (2) and a 19-year-old man with acute lymphocytic leukemia who had measles pneumonia and acute hemorrhagic leukoencephalitis (1). The only fatal case occurred in an immunocompromised 8-year-old boy with giant-cell pneumonia (3).

The identification of hemophagocytosis in bone marrow aspirate represents only 1 of the 5–8 criteria needed for a diagnosis of HLH; conversely, a bone marrow aspirate lacking hemophagocytosis does not rule out the diagnosis of HLH. Still, we believe HLH should be considered for any patient with fever and pancytopenia, especially in the presence of respiratory distress or multiorgan dysfunction. An appropriate therapy could save the patient (Secondary hemophagocytic syndrome in adults: a case series of 18 patients in a single institution and a review of literature; http://dx.doi.org/10.1002/hon.960).

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Chiara Iaria, Maria Silvana Leonardi, Agata Buda, Maria Luisa Toro, and Antonio Cascio
Author affiliations: Azienda Ospedaliera Piemonte-Papardo, Messina, Italy (C. Iaria); and Policlinico “G. Martino” University Hospital, Messina (M.S. Leonardi, A. Buda, M.L. Toro, A. Cascio)

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References

  1. Pearl  PL, Abu-Farsakh  H, Starke  JR, Dreyer  Z, Louis  PT, Kirkpatrick  JB. Neuropathology of two fatal cases of measles in the 1988–1989 Houston epidemic. Pediatr Neurol. 1990;6:12630. DOIPubMedGoogle Scholar
  2. Komatsuda  A, Chubachi  A, Miura  AB. Virus-associated hemophagocytic syndrome due to measles accompanied by acute respiratory failure. Intern Med. 1995;34:2036. DOIPubMedGoogle Scholar
  3. Nakano  T, Shimono  Y, Sugiyama  K, Nishihara  H, Higashigawa  M, Komada  Y, Clinical features of measles in immunocompromised children. Acta Paediatr Jpn. 1996;38:2127. DOIPubMedGoogle Scholar
  4. Yamamoto  K, Otake  M, Takayanagi  M. Therapeutic effect of cyclosporin A combined with methylprednisolone pulse therapy on hemophagocytic syndrome with the central nervous system involvement [in Japanese]. No To Hattatsu. 2002;34:6671.PubMedGoogle Scholar
  5. Joshi  R, Phatarpekar  A, Currimbhoy  Z, Desai  M. Haemophagocytic lymphohistiocytosis: a case series from Mumbai. Ann Trop Paediatr. 2011;31:13540. DOIPubMedGoogle Scholar

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Cite This Article

DOI: 10.3201/eid1809.120235

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In Response: We thank Iaria et al. (1) for their comments on our letter reporting an unusual case of fatal measles without rash in an immunocompetent woman who manifested cytopenias and an intractable acute respiratory distress syndrome (2). The authors suggest that secondary hemophagocytic lymphohistiocytosis (HLH) could have been considered in this patient. Our reply supplies supplementary clinical and laboratory findings that could be useful for discussion.

During our patient’s hospitalization, we were able to investigate 6/8 diagnostic criteria for HLH proposed by the Histiocyte Society (3). Of these, only 2 or 3 were found: persistent fever at 38.5°C; hypertriglyceridemia at 267 mg/dL (analysis performed at day 7); and cytopenias, which preferentially affected erythrocytes and lymphocytes. (Thrombocytopenia was moderate at >100 × 109 platelets/L, and no neutropenia was found [>2 × 109 neutrophils/L].) Liver function was not affected; no hepatomegaly was found, and alanine aminotransferase, aspartate aminotransferase, and bilirubin levels remained within reference ranges. Physical examinations did not detect splenomegaly, and laboratory findings did not show hypofibrinogenemia or ferritin level exceeding 500 ng/mL. A bone marrow biopsy performed on day 2 of hospitalization did not show hemophagocytosis. Studies of natural killer cell function and soluble CD25, which are also proposed diagnostic criteria for HLH, were not performed.

Overall, we found that the arguments in favor of HLH were too limited to consider this diagnosis and initiate an aggressive therapeutic approach based on immunosuppressive drugs. Even if, in the event of HLH, an early and appropriate treatment can be life-saving, the destruction of the remaining immune functions might also be lethal for the patient.

Julien Lupo, Laboratoire de Virologie, Institut de Biologie et Pathologie Centre Hospitalier Universitaire de Grenoble, BP 217, Grenoble Cedex 9 38043, France
Author affiliations: Centre Hospitalier Universitaire de Grenoble and Université Joseph Fourier, Grenoble, France

References

  1. Iaria  C, Leonardi  MS, Buda  A, Toro  ML, Cascio  A. Measles and secondary hemophagocytic lymphohistiocytosis [letter]. Emerg Infect Dis. 2012;18:1529. DOIGoogle Scholar
  2. Lupo  J, Bernard  S, Wintenberger  C, Baccard  M, Vabret  A, Antona  D, Fatal measles without rash in Immunocompetent adult, France. Emerg Infect Dis. 2012;18:5213. DOIPubMedGoogle Scholar
  3. Janka  GE. Familial and acquired hemophagocytic lymphohistiocytosis. Annu Rev Med. 2012;63:23346. DOIPubMedGoogle Scholar

Table of Contents – Volume 18, Number 9—September 2012

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Page created: August 15, 2012
Page updated: August 15, 2012
Page reviewed: August 15, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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