Figure. . . Alignment of deduced amino acid sequences for ON1 isolates from South Africa (Patient 1–8, accession nos. JX885730–JX885737) and Canada (ON67 and ON138) with NA1 isolates (Patient 9–12) from South Africa. A) Variable domain sequence copied, B) Duplicated sequence inserted into variable domain, C) Characteristic amino acid substitutions that distinguish ON1 from NA1. D) Amino acid substitution (E308K) (position 284 before insertion) that distinguishes between most ON1 isolates from South Africa (Patient 2–8) from those from Canada (ON67 and ON138) ON1.