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Volume 19, Number 9—September 2013

Powassan Meningoencephalitis, New York, New York, USA

Simon Sung1Comments to Author , Alysse G. Wurcel1, Susan Whittier, Karen Kulas, Laura D. Kramer, Robin Flam, James Kirkland Roberts, and Simon Tsiouris
Author affiliations: Columbia University, New York City, New York, USA (S. Sung, A.G. Wurcel, S. Whittier, R. Flam, J.K. Roberts, S. Tsiouris); Tufts Medical Center, Boston, Massachusetts, USA (A.G. Wurcel); New York State Department of Health, Albany, New York, USA (K. Kulas, L.D. Kramer); Mid Hudson Medical Group, Hopewell Junction, New York, USA (R. Flam)

Main Article


Results of initial arboviral serologic testing and POWV RT-PCR on CSF from 2 patients, performed at Wadsworth Center, New York State Department of Health, New York, USA*

Test Test result, month
Patient 1, 2009 Patient 2, 2012
West Nile virus IgM ELISA Nonreactive, Feb Nonreactive, May
Eastern equine encephalitis virus IgG IFA <16, Feb <16, May
Western equine encephalitis virus IgG IFA <16, Feb <16, May
California serogroup IgG IFA <16, Feb <16, May
St. Louis encephalitis virus IgG IFA <16, Feb <16, May
rPOW-E polyvalent MIA† (titer) Reactive, Feb Reactive, May
Powassan PRNT (titer) + (20), Feb + (280), early May
+ (320), Mar + (320), late May
+ (160), early Jun
+ (10), late Jun
Powassan RT-PCR CSF Not done

*POWV, Powassan virus; RT-PCR, reverse transcription PCR; CSF, cerebrospinal fluid; IFA, immunofluorescent assay; MIA, microsphere immunoassay; PRNT, plaque reduction neutralizing test;; +, positive; –, negative.
†A fluorescent MIA technique using recombinant POWV envelope glycoprotein antigen to detect IgG, IgA, and IgM.

Main Article

1These authors contributed equally to this article.

Page created: August 20, 2013
Page updated: August 20, 2013
Page reviewed: August 20, 2013
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