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Volume 20, Number 6—June 2014

Characteristics of Patients with Mild to Moderate Primary Pulmonary Coccidioidomycosis

Janis E. BlairComments to Author , Yu-Hui H. Chang, Meng-Ru Cheng, Laszlo T. Vaszar, Holenarasipur R. Vikram, Robert Orenstein, Shimon Kusne, Stanford Ho, Maria T. Seville, and James M. Parish
Author affiliations: Mayo Clinic Hospital, Phoenix, Arizona, USA (J.E. Blair, H.R. Vikram, R. Orenstein, S. Kusne, M.T. Seville); Mayo Clinic, Scottsdale, Arizona, USA (Y.-H. H. Chang, M.-R. Cheng, L.T. Vaszar, J.M. Parish); Arizona State University, Tempe, Arizona, USA (S. Ho)

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Table 2

Comparison of onset of symptoms to time to study end points among 36 patients with primary pulmonary coccidioidomycosis, Arizona, USA, March 1, 2010– October 31, 2012*

Study end point Antifungal treatment
p value
Yes, n = 20 No, n = 16
Time to 50% reduction in symptom score, wk 0.84†
Median 9.9 9.1
Q1, Q3 7.0, 13.4 7.4, 17.1


Time to complete symptom resolution, wk 0.65‡
Median 18.7 17.8
Q1, Q3 13.6, 25.0 12.1, 24.0


Time to 50% reduction in fatigue, wk§ 0.59‡
Median 12.9 9.8
Q1, Q3 8.0, 16.0 8.4, 15.9


Time to full attendance at work, wk 0.02†
Median 8.4 5.7
Q1, Q3 6.7, 14.8 5.1, 6.0


Time to full attendance at school, wk
Median 13.7
Q1, Q3

13.7, 13.7

Time to 50% improvement in PCS, wk 0.08‡
Median 20.4 13.8
Q1, Q3

14.7, 26.0
10.4, 18.0

Time to 50% improvement in MCS, wk 0.21‡
Median 12.0 8.1
Q1, Q3 9.3, 14.7 6.6, 9.7

*Q1, first quartile; Q3, third quartile; PCS, physical activity score as measured on the SF-36 General Health Survey; MCS, mental activity score as measured on the SF-36 General Health Survey.
†By the Wilcoxon rank–sum test.
‡By the equal variance t test.
§As reported on the Fatigue Severity Scale.

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Page created: May 16, 2014
Page updated: May 16, 2014
Page reviewed: May 16, 2014
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