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Volume 21, Number 1—January 2015

Diverse Francisella tularensis Strains and Oropharyngeal Tularemia, Turkey

Yasemin Özsürekci1, Dawn N. Birdsell1, Melda Çelik, Eda Karadağ-Öncel, Anders Johansson, Mats Forsman, Amy J. Vogler, Paul Keim, Mehmet Ceyhan, and David M. WagnerComments to Author 
Author affiliations: Author affiliations: Hacettepe University, Ankara, Turkey (Y. Özsürekci, M. Çelik, E. Karadağ-Öncel, M. Ceyhan); Northern Arizona University, Flagstaff, Arizona, USA (D.N. Birdsell, A.J. Vogler, P. Keim, D.M. Wagner); Umeå University, Umeå, Sweden (A. Johansson); Swedish Defence Research Agency, Umeå (M. Forsman); Translational Genomics Research Institute, Flagstaff (P. Keim)

Main Article


Francisella tularensis–positive clinical samples from 14 patients with oropharyngeal tularemia, Turkey, December 2009–January 2011*

Patient no. (sample no.) City CanSNP subgroup† MLVA genotype‡
1 (F0737) Corum B.20/21/33 i
2 (F0738) Cankırı B.28/29 b
3 (F0739) Yozgat B.28/29 b
4 (F0740) Zonguldak B.7/8 a
5 (F0741) Corum B.20/21/33 e
6 (F0742) Corum B.20/21/33 e
7 (F0743) Corum B.20/21/33§ ND
8 (F0744)¶ Bala/Ankara B.20/21/33 e
9 (F0745) Ankara B.20/21/33 d
10 (F0746) Corum B.20/21/33 j
11 (F0747) Bala/Ankara B.20/21/33 g
12 (F0748) Corum B.20/21/33 f
13 (F0749) Ankara B.20/21/33 c
14 (F0750) Emirdağ/Afyon B.20/21/33 h

*Clinical samples collected in 2011 from patients with cervical lymphadenitis at Hacettepe University Medical Faculty, Pediatric Infectious Disease unit, Ankara, Turkey. CanSNP, canonical single-nucleotide polymorphism; MLVA, multilocus variable-number tandem-repeat analysis; ND, not determined.
†Subgroups published in (3,4,6,7). CanSNP branches tested on samples in this study: B.3, B.4, B.5, B.6, B.7, B.8, B.9, B.10, B.11, B.13, B.20, B.21, B.22, B.26, B.27, B.28, B.29, B.30, B.31, B.32, and B.33.
‡MLVA markers (M03, M05, M06, M20) (2).
§Subgroup classification based on approximation because genotype for B.33 remains unresolved.
¶This patient was an adult (all others were children).

Main Article

  1. Akalin  H, Helvaci  S, Gedikoglu  S. Re-emergence of tularemia in Turkey. Int J Infect Dis. 2009;13:54751 .DOIPubMedGoogle Scholar
  2. Vogler  AJ, Birdsell  D, Wagner  DM, Keim  P. An optimized, multiplexed multi-locus variable-number tandem repeat analysis system for genotyping Francisella tularensis. Lett Appl Microbiol. 2009;48:1404. DOIPubMedGoogle Scholar
  3. Chanturia  G, Birdsell  DN, Kekelidze  M, Zhgenti  E, Babuadze  G, Tsertsvadze  N, Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia. BMC Microbiol. 2011;11:139 . DOIPubMedGoogle Scholar
  4. Gyuranecz  M, Birdsell  DN, Splettstoesser  W, Seibold  E, Beckstrom-Sternberg  SM, Makrai  L, Phylogeography of Francisella tularensis subsp. holarctica, Europe. Emerg Infect Dis. 2012;18:2903. DOIPubMedGoogle Scholar
  5. Karlsson  E, Svensson  K, Lindgren  P, Byström  M, Sjödin  A, Forsman  M, The phylogeographic pattern of Francisella tularensis in Sweden indicates a Scandinavian origin of Eurosiberian tularaemia. Environ Microbiol. 2013;15:63445. DOIPubMedGoogle Scholar
  6. Svensson  K, Granberg  M, Karlsson  L, Neubauerova  V, Forsman  M, Johansson  A. A real-time PCR array for hierarchical identification of Francisella isolates. PLoS ONE. 2009;4:e8360. DOIPubMedGoogle Scholar
  7. Vogler  AJ, Birdsell  D, Price  LB, Bowers  JR, Beckstrom-Sternberg  SM, Auerbach  RK, Phylogeography of Francisella tularensis: global expansion of a highly fit clone. J Bacteriol. 2009;191:247484. DOIPubMedGoogle Scholar
  8. Ulu-Kilic  A, Gulen  G, Sezen  F, Kilic  S, Sencan  I. Tularemia in central Anatolia. Infection. 2013;41:3919. DOIPubMedGoogle Scholar
  9. Johansson  A, Berglund  L, Eriksson  U, Goransson  I, Wollin  R, Forsman  M, Comparative analysis of PCR versus culture for diagnosis of ulceroglandular tularemia. J Clin Microbiol. 2000;38:226 .PubMedGoogle Scholar
  10. Wang  Y, Peng  Y, Hai  R, Xia  L, Li  H, Zhang  Z, Diversity of Francisella tularensis subsp. holarctica lineages, China. Emerg Infect Dis. 2014;20:11914. DOIPubMedGoogle Scholar

Main Article

1These authors contributed equally to this article.

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