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Volume 21, Number 11—November 2015
CME ACTIVITY - Synopsis

Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA

Dong Sik Jung1, Dimitrios Farmakiotis12, Ying Jiang, Jeffrey J. Tarrand, and Dimitrios P. KontoyiannisComments to Author 
Author affiliations: Dong-A University College of Medicine, Busan, South Korea (D.S. Jung); The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (D.S. Jung, D. Farmakiotis, Y. Jiang, J.J. Tarrand, D.P. Kontoyiannis); Brigham and Women’s Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts, USA (D. Farmakiotis)

Main Article

Table 5

Factors associated with 28-day crude mortality rate among cancer patients with candidemia caused by uncommon Candida species, Houston, Texas, USA*

Variable Univariate analysis
 Multivariate analysis
Hazard ratio (95% CI) p value Adjusted hazard ratio (95% CI) p value
Underlying leukemia 7.6 (2.47–23.14) <0.001 NR
Steroid exposure 3.0 (1.03–8.71) 0.040 NR
ICU admission 26.4 (6.42–108.55) <0.001 4.0 (1.8–9.05) 0.001
Intubation 8.3 (1–69.64) 0.040 NR
Total parenteral nutrition 4.0 (0.80–20.02 0.105 NR
Persistent neutropenia† 30.6 (3.77–247.93) <0.001 3.0 (1.52–6.05) 0.002
APACHE II score ≥19 12.8 (3.27–49.93) <0.001 2.8 (1.39–5.78) 0.004
Hypoalbuminemia‡ 3.5 (1.10–11.45) 0.030 NR
Breakthrough fungemia 4.4 (1.53–12.64) 0.005 NR

*NR, not retained in the multivariate analysis model; APACHE II, Acute Physiology and Chronic Health Evaluation II.
†Persistent neutropenia was defined as an absolute neutrophil count of <500/μL for ≥7 days.
‡Serum albumin level <3.0 g/dL.

Main Article

1These authors contributed equally to this article.

2Current affiliation: Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Page created: October 19, 2015
Page updated: October 19, 2015
Page reviewed: October 19, 2015
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