Table 4

Risk Factors for Acquisition of Drug Resistance during Multidrug-Resistant Tuberculosis Treatment, Arkhangelsk Oblast, Russia, 2005–2010

Sarah E. Smith

, Julia Ershova, Natalia Vlasova, Elena Nikishova, Irina Tarasova, Platon Eliseev, Andrey Maryandyshev, Igor G. Shemyakin, Ekaterina V. Kurbatova, and J. Peter Cegielski

Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.E. Smith, J. Ershova, E. Kurbatova, J.P. Cegielski); Arkhangelsk Regional Tuberculosis Dispensary, Arkhangelsk, Russia (N. Vlasova, E. Nikishova, I. Tarasova, P. Eliseev, A.O. Maryandyshev); Northern State Medical University, Arkhangelsk (A.O. Maryandyshev); State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia (I.G. Shemyakin)

Main Article

Risk factors for acquiring extensive drug resistance during MDR TB treatment, 164 patients, Arkhangelsk, Russia, 2005–2010*

Variable†	Total	Acquired extensive drug resistance, no. (%)		p value‡
Variable†	Total	Yes	No	p value‡
Treated with ≥3 effective drugs
Yes	129	1 (0.8)	128 (99.2)	0.03
No	35	3 (8.6)	32 (91.4)
Ever received effective FQ§
Yes	160	3 (1.9)	157 (98.1)	0.07
No	3	1 (33.3)	2 (66.7)
Body mass index <18.5 at MDR TB diagnosis
Yes	36	3 (8.3)	33 (91.7)	0.03
No	128	1 (0.8)	127 (99.2)
Baseline OFX susceptibility result
Resistant	3	1 (33.3)	2 (66.7)	0.07
Susceptible	161	3 (1.9)	158 (98.1)
Ever received OFX during current episode
Yes	144	2 (1.4)	142 (98.6)	0.07
No	20	2 (10)	18 (90)
Ever received MOX during current episode
Yes	29	3 (10.3)	26 (89.7)	0.02
No	135	1 (0.7)	134 (99.3)

*FQ, fluoroquinolone; OFX, ofloxacin; MDR TB, multidrug-resistant tuberculosis; MOX, moxifloxicin
†Certain variables were tested for association but omitted from table because results were not statistically significant at α = 0.1.
‡Fisher exact test.
§Patients who did not receive treatment with the respective drug during the current episode of MDR TB were not included in the analysis.

Main Article

Page created: May 15, 2015

Page updated: May 15, 2015

Page reviewed: May 15, 2015

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