Volume 22, Number 2—February 2016
CME ACTIVITY - Research
Molecular Characterization of Invasive Streptococcus dysgalactiae subsp. equisimilis, Japan
Takeaki Wajima1, Miyuki Morozumi1, Shigeo Hanada, Katsuhiko Sunaoshi, Naoko Chiba, Satoshi Iwata, and Kimiko Ubukata
Table 3
Correlation of emm type and macrolide or quinolone resistance genes among Streptococcus dysgalactiae subsp. equisimilis isolates, Japan, April 2010–March 2013*
| emm type | Total no. strains | No. (%) macrolide resistance |
Total no. (%) resistance | p value | No. (%) quinolone resistance† |
Total no. (%) resistance | p value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| erm(A) | erm(B) | mef(A) | gyrA + parC | parC | ||||||
| stG6792 | 188 | 10 (5.3) | 7 (3.7) | 7 (3.7) | 24 (12.8) | 0.018 | 2 (1.1) | 3 (1.6) | 5 (2.7) | 0.950 |
| stG485 | 92 | 12 (13.0) | 1 (1.1) | 2 (2.2) | 15 (16.3) | 0.565 | 4 (4.3) | 4 (4.3) | 0.257 | |
| stG245 | 74 | 1 (1.4) | 37 (50.0) | 38 (51.4) | <0.001 | 1 (1.4) | 1 (1.4) | 0.476 | ||
| stG652 | 47 | 6 (12.8) | 1 (2.1) | 7 (14.9) | 0.513 | 3 (6.4) | 3 (6.4) | 0.091 | ||
| seG10 | 43 | 10 (23.3) | 8 (18.6) | 1(2.3) | 19 (44.2) | <0.001 | 1 (2.3) | 1 (2.3) | 0.908 | |
| stG6 | 38 | 2 (5.3) | 1 (2.6) | 1 (2.6) | 4 (10.5) | 0.194 | 0 | – | ||
| stG653 | 27 | 0 | – | 1 (3.7) | 1 (3.7) | 0.712 | ||||
| stG2078 | 26 | 6 (23.1) | 1 (3.8) | 7 (26.9) | 0.656 | 1 (3.8) | 1 (3.8) | 0.725 | ||
| stC36 | 25 | 1 (4.0) | 1 (4.0) | 2 (8.0) | 0.169 | 0 | – | |||
| stC74a | 18 | 2 (11.1) | 2 (11.1) | 0.415 | 0 | – | ||||
| stG166b | 17 | 0 | – | 0 | – | |||||
| stG480 | 16 | 2 (12.5) | 2 (12.5) | 0.534 | 0 | – | ||||
| stG5420 | 15 | 0 | – | 1 (6.7) | 1 (6.7) | 0.316 | ||||
| stC6979 | 13 | 1 (7.7) | 1 (7.7) | 0.312 | 0 | – | ||||
| stG4222 | 10 | 0 | – | 0 | – | |||||
| stG4974 | 10 | 2 (20.0) | 2 (20.0) | 0.900 | 1 (10.0) | 1 (10.0) | 0.138 | |||
| Others | 34 | 4 (11.8) | 1 (2.9) | 5 (14.7) | 0.562 | 0 | – | |||
| Total | 693 | 55 (7.9) | 62 (8.9) | 11 (1.6) | 128 (18.5) | 11 (1.6) | 7 (1.0) | 18 (2.6) | ||
*Dashes indicate p value not determined because of the small number of strains. Blank cells indicate 0.
†Mutations in gyrA gene: Ser81Phe (n = 8) and Ser81Tyr (n = 3). Mutation in parC genes: Ser79Phe (n = 16), Ser79Tyr (n = 1), Asp83Gly (n = 1).
1These authors contributed equally to this article.
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