Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus
Gary Crameri, Peter A. Durr
, Reuben Klein, Adam Foord, Meng Yu, Sarah Riddell, Jessica Haining, Dayna Johnson, Maged G. Hemida, Jennifer Barr, Myoung-don Oh, Deborah Middleton, and Lin-Fa Wang
Author affiliations: CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia (G. Crameri, P.A. Durr, R. Klein, A. Foord, M. Yu, S. Riddell, J. Haining, D. Johnson, J. Barr, D. Middleton); Kafrelsheikh University, Kafr Elsheikh, Egypt (M.G. Hemida); King Faisal University, Hofuf, Saudi Arabia (M.G. Hemida); University of Hong Kong, Hong Kong, China (M. Peiris); Duke–National University of Singapore Medical School, Singapore (L.-F. Wang)
Figure. Virus shedding of MERS-CoV from 3 infected alpacas as detected from the deep nasal swab samples by day after initial infection and reinfection. Viral load was estimated from real-time cycle threshold values and a calibration experiment. Arrow indicates day 21, when the animals were reinfected with MERS-CoV. MERS-COV, Middle East respiratory syndrome coronavirus; TCID, tissue culture infective dose.
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