Volume 23, Number 12—December 2017
Research
Outbreaks of Neuroinvasive Astrovirus Associated with Encephalomyelitis, Weakness, and Paralysis among Weaned Pigs, Hungary
Table 1
Data |
Symptomatic animals† |
Asymptomatic control animals† |
|||||||||
GD-1 |
GD-2 |
GD-3 |
GD-4 |
GD-5 |
GD-6 |
GD-7 |
GD-8 |
GD-9 |
GD-10 |
||
Collection month | 2016 Mar | 2016 Mar | 2016 Jul | 2016 Jul | 2015 Nov | 2016 Jul | 2017 Jun | 2017 Jun | 2017 Jun | 2017 Jun | |
Age, d | 25 | 25 | 25 | 25 | 35 | 35 | 25 | 25 | 25 | 35 | |
Clinical signs (disease stage) |
PP
(1) |
PP
(1) |
PP
(3) |
PP
(3) |
PP (3) |
None |
None |
None |
None |
None |
|
Brain stem |
+ |
+ |
+ |
+ |
+ |
– (–) |
– (–) |
– (–) |
– (–) |
– (–) |
|
Spinal cord | |||||||||||
Cervical | NA | NA | + | + | NA | NA | – (–) | – (–) | NA | NA | |
Thoracic | NA | NA | + | + | NA | NA | – (–) | – (–) | NA | NA | |
Lumbar |
+ |
NA |
+ |
+ |
+ |
– (–) |
– (–) |
– (–) |
NA |
NA |
|
Nasal mucosa | – (+)‡ | +‡ | + | + | NA | – (–) | – (–)‡ | – (–)‡ | – (–)‡ | – (–)‡ | |
Lung | NA | NA | + | + | NA | NA | NA | NA | NA | NA | |
Tonsils | NA | – (–) | + | + | + | – (–) | NA | NA | NA | NA | |
Salivary glands | NA | NA | – (+) | + | NA | NA | NA | NA | NA | NA | |
Myocardium | NA | + | NA | NA | + | NA | NA | NA | NA | NA | |
Feces | – (–) | NA | – (+) | – (+) | NA | NA | – (–) | – (–) | – (–) | – (–) | |
Ileum |
NA |
NA |
– (–) |
– (+) |
– (–) |
– (–) |
NA |
NA |
NA |
NA |
|
Lymph nodes | |||||||||||
Mesenterial | NA | – (–) | – (–) | – (–) | NA | – (–) | NA | NA | NA | NA | |
Submandibular |
NA |
NA |
– (+) |
+ |
NA |
NA |
NA |
NA |
NA |
NA |
|
Urine | NA | NA | – (–) | – (–) | NA | NA | NA | NA | NA | NA | |
Kidney | NA | NA | – (–) | – (–) | NA | NA | NA | NA | NA | NA | |
Liver | NA | NA | – (+) | – (+) | NA | NA | NA | NA | NA | NA | |
Spleen | NA | NA | – (–) | – (–) | NA | NA | NA | NA | NA | NA | |
Serum | NA | NA | + | + | NA | NA | NA | NA | NA | NA |
*We collected tissues from 5 affected pigs with encephalomyelitis and PP and 5 asymptomatic control animals from the index farm. The screening nested RT-PCR primers are designed to the RNA-dependent RNA polymerase region of PoAstV-3. NA, no available sample; PoAstV-3, porcine astrovirus type 3; PP, posterior paraplegia; RT-PCR, reverse transcription PCR; +, positive; −, negative.
†Symbols indicate results from first PCR reactions; symbols in parentheses indicate results from second (nested) RT-PCR reactions.
‡Nasal swab sample.
Page created: November 16, 2017
Page updated: November 16, 2017
Page reviewed: November 16, 2017
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