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Volume 24, Number 10—October 2018
Dispatch

Emerging Enteroviruses Causing Hand, Foot and Mouth Disease, China, 2010–2016

Yu Li1, Zhaorui Chang1, Peng Wu1, Qiaohong Liao, Fengfeng Liu, Yaming Zheng, Li Luo, Yonghong Zhou, Qi Chen, Shuanbao Yu, Chun Guo, Zhenhua Chen, Lu Long, Shanlu Zhao, Bingyi Yang, Hongjie Yu2Comments to Author , and Benjamin J. Cowling
Author affiliations: Chinese Center for Disease Control and Prevention. Beijing, China (Y. Li, Z. Chang, Q. Liao, F. Liu, Y. Zheng, L. Luo, S. Yu, H. Yu); The University of Hong Kong, Hong Kong, China (Y. Li, P. Wu, B. Yang, B.J. Cowling); Fudan University, Shanghai, China (Y. Zhou, H. Yu); Hubei Center for Disease Prevention and Control, Wuhan, China (Q. Chen); Huazhong University of Science and Technology, Wuhan, China (C. Guo); Chengdu Center for Disease Prevention and Control, Chengdu, China (Z. Chen); Sichuan University, Chengdu, China (L. Long); Hunan Center for Disease Prevention and Control, Changsha, China (S. Zhao)

Main Article

Table

Serotypes of non–EV-A71 and non–CV-A16 enteroviruses among HFMD cases, by clinical severity, 2013 and 2015, China*

Test result
 2013, no. (%)
2015, no. (%)
Mild, n = 87,226
 Severe, n = 3,837
 Mild, n = 99,461
 Severe, n = 4,712
EV negative 32,801 (37.60) 1,100 (28.67) 35,167 (35.36) 1,273 (27.02)
EV-A71 15,503 (17.77) 1,557 (40.58) 11,800 (11.86) 1,352 (28.69)
CV-A16 10,811 (12.39) 197 (5.13) 13,959 (14.03) 265 (5.62)
Other enteroviruses 28,111 (32.23) 983 (25.62) 38,535 (38.74) 1,822 (38.67)
Further serotyping of other enteroviruses
Total Mild, n = 3,260† Severe, n = 42‡ Mild, n = 2,474§ Severe, n = 71¶
CV-A6 2,620 (80.37) 28 (66.67) 1,471 (59.46) 31 (43.70)
CV-A10 176 (5.40) 4 (9.52) 104 (4.20) #
CV-A2 22 (0.67) 1 (2.38) 5 (0.20) #
CV-A5 9 (0.28) 1 (2.38) 2 (0.08) #
CV-A4 2 (0.06) # 9 (0.36) #
ECV-6 9 (0.28) # # #
CV-B4 13 (0.4) # # #
ECV-25 8 (0.25) # # #
CV-A12 5 (0.15) # # #
CV-B5 5 (0.15) # # #
CV-B2 4 (0.12) # 1 (0.04) #
ECV-7 4 (0.12) # # #
ECV-9 3 (0.09) # # #
CV-A8 1 (0.03) # 3 (0.12) #
CV-A14 2 (0.06) # # #
CV-A21 2 (0.06) # # #
ECV-12 2 (0.06) # # #
CV-B1 2 (0.06) # # #
ECV-30 1 (0.03) # 1 (0.04) #
Other 6 (0.18)** # # #
Untyped 364 (11.37)      8 (19.05) 878 (35.49)       40 (56.34)

*CV, coxsackievirus; ECV, echovirus; EV, enterovirus.
†Results are based on data from Beijing, Fujian, Guangdong, Guangxi, Heilongjiang, Henan, Hubei, Jiangsu, Jilin, Shanxi, Sichuan, Shandong, Tianjin, Xinjiang, and Yunnan provinces.
‡Results are based on data from Fujian, Guangdong, Guangxi, Henan, and Shanxi provinces.
§Results are based on data from Beijing, Fujian, Guangxi, Heilongjiang, Jiangsu, Sichuan, Tianjin, and Zhejiang provinces.
¶Results are based on data from Guangdong and Jiangsu provinces.
#The serotypes were not detected, but might be included in the untyped specimens because of laboratory capacity restrictions.
**Other serotypes include CV-A20, CV-A24, ECV-1, ECV-96, Polio1, and Polio2, with 1 of each serotype detected.

Main Article

1These authors contributed equally to this article.

2Current affiliation: Fudan University School of Public Health, Shanghai, China.

Page created: September 16, 2018
Page updated: September 16, 2018
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