Volume 24, Number 3—March 2018
Research
Influenza Vaccination and Incident Tuberculosis among Elderly Persons, Taiwan1
Yung-Feng Yen2, Sheng-Wei Pan, Vincent Yi-Fong Su2, Pei-Hung Chuang, Jia-Yih Feng3
, and Wei-Juin Su3
, and Wei-Juin Su3
Table 2
Univariate and multivariate analyses of the protective and risk factors for incident TB among elderly persons with and without influenza vaccination, Taiwan, 2005–2012*
| Characteristic | Person-years | Incidence density† | Univariate analysis, HR (95% CI) | Multivariate analysis, adjusted HR (95% CI) |
|---|---|---|---|---|
| Influenza vaccination | ||||
| No | 227,910.5 | 175.5 | 1 | 1 |
| Yes |
510,458.1 |
145.2 |
0.83 (0.73–0.93)‡ |
0.82 (0.73–0.93)‡ |
| Age, y | ||||
| 65–69 | 293,257.6 | 106.4 | 1 | 1 |
| 70–74 | 197,971.8 | 150.5 | 1.41 (1.21–1.66)§ | 1.18 (1.00–1.38)¶ |
| >75 |
247,139.3 |
214.9 |
2.02 (1.75–2.32)§ |
1.43 (1.24–1.66)§ |
| Sex | ||||
| F | 385,893.5 | 62.7 | 1 | 1 |
| M |
352,475.2 |
255.1 |
4.07 (3.53–4.69)§ |
3.32 (2.88–3.84)§ |
| Income level | ||||
| Low | 507,842.5 | 170.9 | 1 | 1 |
| Intermediate | 133,417.7 | 122.9 | 0.72 (0.61–0.85)§ | 0.88 (0.74–1.04) |
| High |
97,108.5 |
112.2 |
0.66 (0.54–0.80)§ |
0.82 (0.67–1.00) |
| Urbanization | ||||
| Urban | 187049.0 | 129.4 | 1 | 1 |
| Suburban | 436275.1 | 157.9 | 1.22 (1.05–1.41)‡ | 1.13 (0.98–1.31) |
| Rural |
115044.5 |
182.5 |
1.41 (1.17–1.70)§ |
1.37 (1.13–1.65)¶ |
| Concurrent conditions | ||||
| Diabetes | ||||
| No | 596,098.4 | 153.5 | 1 | 1 |
| Yes | 142,270.2 | 158.9 | 1.03 (0.89–1.20) | 1.17 (1.02–1.33)¶ |
| CHF | ||||
| No | 708,633.3 | 152.4 | 1 | 1 |
| Yes | 29,735.4 | 205.1 | 1.34 (1.04–1.74)¶ | 1.37 (1.16–1.62)§ |
| COPD | ||||
| No | 621,742.5 | 133.3 | 1 | 1 |
| Yes | 116,626.2 | 267.5 | 2.00 (1.76–2.28)§ | 2.77 (2.43–3.15)§ |
| Asthma | ||||
| No | 676,539.1 | 145.9 | 1 | 1 |
| Yes | 61,829.5 | 249.1 | 1.71 (1.44–2.02)§ | 1.12 (0.96–1.30) |
| CVD | ||||
| No | 631659.3 | 152.0 | 1 | 1 |
| Yes | 106709.3 | 169.6 | 1.11 (0.95–1.31) | 0.89 (0.78–1.02) |
| HTN | ||||
| No | 360268.3 | 156.5 | 1 | 1 |
| Yes | 378100.3 | 152.6 | 0.97 (0.87–1.09) | 0.86 (0.76–0.98)¶ |
| CKD | ||||
| No | 693223.9 | 149.2 | 1 | 1 |
| Yes | 45144.7 | 237.0 | 1.59 (1.30–1.94)§ | 1.31 (1.12–1.53)§ |
| Cancer | ||||
| No | 696681.8 | 150.9 | 1 | 1 |
| Yes | 41686.8 | 215.9 | 1.43 (1.15–1.77)‡ | 1.96 (1.71–2.26)§ |
*CHF, congestive heart failure; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVD, cerebrovascular disease; HR, hazard ratio; HTN, hypertension; TB, tuberculosis.
†Per 100,000 person-years.
‡p<0.01.
§p<0.001.
¶p<0.05.
1The abstract of this study was presented at the 47th Union World Conference on Lung Health in Liverpool, United Kingdom, on October 27, 2016.
2These authors contributed equally to this article.
3These authors contributed equally to this article.
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