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Volume 24, Number 4—April 2018
Research

Carbapenem-Nonsusceptible Acinetobacter baumannii, 8 US Metropolitan Areas, 2012–2015

Sandra N. BulensComments to Author , Sarah H. Yi, Maroya S. Walters, Jesse T. Jacob, Chris Bower, Jessica Reno, Lucy Wilson, Elisabeth Vaeth, Wendy Bamberg, Sarah J. Janelle, Ruth Lynfield, Paula Snippes Vagnone, Kristin Shaw, Marion Kainer, Daniel Muleta, Jacqueline Mounsey, Ghinwa Dumyati, Cathleen Concannon, Zintars Beldavs, P. Maureen Cassidy, Erin C. Phipps, Nicole Kenslow, Emily B. Hancock, and Alexander J. Kallen
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.N. Bulens, S.H. Yi, M.S. Walters, A.J. Kallen); Emory University School of Medicine, Atlanta (J.T. Jacob); Georgia Emerging Infections Program, Atlanta (J.T. Jacob, C. Bower, J. Reno); Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA (C. Bower, J. Reno); Atlanta Research and Education Foundation, Decatur (C. Bower, J. Reno); Maryland Department of Health and Mental Hygiene, Baltimore, Maryland, USA (L. Wilson, E. Vaeth); Colorado Department of Public Health and Environment, Denver, Colorado, USA (W. Bamberg, S.J. Janelle); Minnesota Department of Health, St. Paul, Minnesota, USA (R. Lynfield, P.S. Vagnone, K. Shaw); Tennessee Department of Public Health, Nashville, Tennessee, USA (M. Kainer, D. Muleta, J. Mounsey); New York Rochester Emerging Infections Program at the University of Rochester Medical Center, Rochester, New York, USA (G. Dumyati, C. Concannon); Oregon Health Authority, Portland, Oregon, USA (Z. Beldavs, P.M. Cassidy); University of New Mexico, Albuquerque, New Mexico, USA (E.C. Phipps, N. Kenslow, E.B. Hancock)

Main Article

Table 4

Antimicrobial susceptibility of 621 carbapenem-nonsusceptible Acinetobacter baumannii isolates reported by local clinical laboratories in Emerging Infections Program sites, United States, 2012–2015*

Antimicrobial agent No. susceptible isolates/no. isolates tested (%)
 p value†
Total (%) Sterile site cultures, n = 173 Urine cultures, n = 425
Any aminoglycoside‡ 421/577 (72.9) 123/166 (74.1) 298/411 (72.5) 0.70
Tobramycin 308/541 (56.9) 92/158 (58.2) 216/383 (56.4) 0.70
Amikacin 254/416 (61.1) 71/121 (58.7) 183/295 (62.0) 0.52
Gentamicin
 175/571 (30.7)
 49/163 (30.1)
 126/408 (30.9)
 0.85
Any fluoroquinolone‡ 20/575 (3.5) 1/164 (0.6) 19/411 (4.6) 0.02
Levofloxacin 15/432 (3.5) 1/120 (0.8) 14/312 (4.5) 0.08
Ciprofloxacin
 10/522 (1.9)
 1/145 (0.7)
 9/377 (2.4)
 0.30
Any extended-spectrum β-lactam‡ 114/577 (19.8) 27/165 (16.4) 87/412 (21.1) 0.20
Ceftazidime 72/447 (16.1) 17/129 (13.2) 55/318 (17.3) 0.28
Cefepime 68/562 (12.1) 18/161 (11.2) 50/401 (12.5) 0.67
Piperacillin/tazobactam
 4/113 (3.5)
 1/37 (2.7)
 3/76 (1.9)
 >0.99
Other
Ampicillin/sulbactam 180/498 (36.1) 47/146 (32.2) 133/352 (37.8) 0.24
Colistin 114/122 (93.4) 36/39 (92.3) 78/83 (94.0) 0.73
Trimethoprim/sulfamethoxazole 83/483 (17.2) 26/142 (18.3) 57/341 (16.7) 0.67
Tigecycline 74/120 (61.7) 27/40 (67.5) 47/80 (58.8) 0.35

*The study areas were Denver, Colorado; Atlanta, Georgia; Baltimore, Maryland; Minneapolis/Saint Paul, Minnesota, Albuquerque, New Mexico; Rochester, New York; Portland, Oregon; Nashville, Tennessee.
†The χ2 test or Fisher exact test was used to test the null hypothesis “carbapenem-nonsusceptible A. baumannii isolates antimicrobial susceptibility did not differ for sterile site vs. urine cultures.” Fisher exact test was used when >1 cell sizes was <5.
‡Includes the antimicrobial drugs listed below.

Main Article

Page created: March 19, 2018
Page updated: March 19, 2018
Page reviewed: March 19, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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