Volume 25, Number 6—June 2019
Joint Estimation of Relative Risk for Dengue and Zika Infections, Colombia, 2015–2016
We jointly estimated relative risk for dengue and Zika virus disease (Zika) in Colombia, establishing the spatial association between them at the department and city levels for October 2015–December 2016. Cases of dengue and Zika were allocated to the 87 municipalities of 1 department and the 293 census sections of 1 city in Colombia. We fitted 8 hierarchical Bayesian Poisson joint models of relative risk for dengue and Zika, including area- and disease-specific random effects accounting for several spatial patterns of disease risk (clustered or uncorrelated heterogeneity) within and between both diseases. Most of the dengue and Zika high-risk municipalities varied in their risk distribution; those for Zika were in the northern part of the department and dengue in the southern to northeastern parts. At city level, spatially clustered patterns of dengue high-risk census sections indicated Zika high-risk areas. This information can be used to inform public health decision making.
Dengue and Zika virus disease (hereafter referred to as Zika) are infectious diseases caused by arboviruses in the family Flaviviridae. Dengue virus has 4 serotypes (1–4); serotypes 2 and 3 are associated with severe disease in persons with second dengue infections. Zika virus infection is associated with congenital malformations in babies born from women infected during pregnancy and with Guillain-Barré syndrome in infected adults (1).
Colombia is highly affected by vectorborne diseases. Villar et al. (2) reviewed the dengue epidemic in this country for 2000–2010 and reported an increasing epidemic trend for the period; outbreaks occurred in 2001, 2003, and 2010. In 2016, health authorities in Colombia reported >101,016 dengue cases that resulted in 289 deaths (3) and 9,799 Zika cases that were laboratory confirmed and 96,860 suspected Zika cases diagnosed by clinical signs (4).
For this study, we concentrated on the spatial patterns assessment of risk for dengue and Zika; in particular, we focused on the relative risk (RR) estimation for areal data by using hierarchical Bayesian models for these infections. RR represents the excess (or lack) of risk in a small area compared with the background risk. RR is mostly based on models and supported by Bayesian estimation methods (5). We used the following as study regions: the municipalities in the department of Santander, Colombia (1 of the departments where incidence of dengue and Zika for 2015–2016 was highest), and the city census sections belonging to the capital city of Santander (1 of the cities most affected by dengue and Zika for the same period).
Racloz et al. (6) and Louis et al. (7) reviewed the spatial patterns assessment of dengue risk; specifically for RR estimation of dengue, Ferreira and Schmidt (8) and Martínez-Bello et al. (9) estimated RR for dengue on a local spatial scale; and Restrepo et al. (10) and Martínez-Bello et al. (11) applied methods for the spatiotemporal assessment of dengue risk. Examples for the spatial patterns assessment of Zika risk run from merely descriptive methods to model-based approaches. For instance, in Colombia, descriptive risk maps associating Zika incidence rates with environmental and sociodemographic factors have been produced in the departments of Sucre (12), Tolima (13), Guajira (14), Santander, and Norte de Santander (15) and in the city of Pereira in the department of Risaralda (16). Model-based spatial patterns assessment of Zika risk have been developed for the 33 departments in Colombia by using Poisson models for the RR for Zika (17). The distribution of risk for Zika transmission among counties/districts in Guangdong Province, China, was assessed by using analytic hierarchy process models (18).
Zika, dengue, and chikungunya are also jointly studied by using the spatial patterns assessment of risk because the viruses share similar transmission routes (Aedes mosquitoes). On a large scale in Brazil, ecological studies have explored the risk factors for unusual spatial patterns of microcephaly, including dengue, Zika, and chikungunya data (19). Also estimated is the potential spatial risk for Zika and chikungunya according to socioenvironmental factors, estimating the size of the populations at risk for both diseases (20). On a small geographic scale, the risk factors for cocirculating arboviruses (dengue, Zika, chikungunya) at the community level have been evaluated (21).
In Colombia, Krystosik et al. (22) generated city-level risk maps of chikungunya, Zika, and dengue supporting vector-control strategies; Martínez-Bello et al. (23) estimated the RR for dengue and Zika by using spatiotemporal interaction effects models for 1 department and 1 city in Colombia. Riou et al. (24) assessed the spatial patterns of risk for the 2013 Zika and chikungunya outbreaks in the French Polynesia islands, and Funk et al. (25) jointly modeled Zika and dengue time series data from the Zika outbreak in Yap Island in the Pacific Ocean.
Our aim with this study was to jointly estimate the disease- and area-specific RRs for dengue and Zika by using hierarchical Bayesian joint models accounting for the spatial association between both diseases. We used data from the 2015–2016 Zika outbreak in Colombia and analyzed 2 levels of spatial data aggregation: the department level (disease counts aggregated per municipality) in the department of Santander and the city level (disease counts aggregated per census section) in the city of Bucaramanga (Santander).
Colombia (Figure 1, panel A), population 48.7 million, comprises ≈1.14 million km2 divided into 33 administrative regions called departments, each 49.6–110,029.4 km2 (Table 1). The department of Santander (Figure 1, panel B) covers 30,642 km2, is divided into 87 municipalities, and has >2 million inhabitants. Santander is in the northeastern region of Colombia, and its administrative center, Bucaramanga (Figure 1, panel C), is in the northeastern region of the department. Bucaramanga covers 162 km2 (urban area 49.6 km2), is divided into 293 urban census sections, and according to the 2016 census has a population of 528,575.
The Zika epidemic started on August 9, 2015 (26). Up to the first epidemiologic week of 2017, Colombia reported 106,659 Zika cases (219 cases/100,000 population) that were suspected by clinical signs and confirmed by laboratory. For the epidemiologic year 2016, the country reported 101,016 dengue cases (207.6 cases/100,000 population; Table 2). Since 2001, one of the departments with the highest dengue incidence in Colombia has been Santander (2); in 2016, its dengue incidence was the sixth highest among the 33 departments (331.63 cases/100,000 population) (3); in 2015–2016, its Zika incidence was the seventh highest (493.09 cases/100,000 population) (4). The incidence rate for Zika in Santander was higher than the national average, accounting for 9.76% of the total cases in Colombia (3). With regard to dengue, in 2016 Santander reported 6.67% of the total cases for Colombia (Table 2). Within the department, 35.52% of Zika cases (692.81/100,000) and 35.62% of dengue cases (467.3/100,000) were reported in Bucaramanga (Table 2).
We aggregated cases of dengue and Zika for the study period (from epidemiologic week 42 in 2015 through epidemiologic week 52 in 2016) obtained from SIVIGILA (the public health surveillance system of Colombia) in the 87 municipalities of Santander by using cartography from the National Geostatistical Framework (27). The case definitions for dengue and Zika correspond to codes 210 (dengue), 220 (severe dengue), 580 (dengue mortality), and 895 (Zika), obtained from the SIVIGILA protocols for dengue (28) and Zika (29). We calculated expected values of dengue and Zika by municipality by using 2016 population projections provided by the Colombia Administrative Department of National Statistics. We first calculated incidence rates for dengue and Zika for 5-year patient age groups and for sex on the basis of observed cases recorded during the study period. We then multiplied these age- and sex-specific incidence rates to the population structure of each municipality, generating disease-specific expected values for both diseases. Last, we aggregated the age- and sex-specific expected values per municipality of dengue and Zika to obtain standardized expected counts per municipality for dengue and Zika.
Cases of dengue and Zika, notified in Bucaramanga and obtained from SIVIGILA for the study period, were geocoded and allocated to 293 census sections in the city (27). A census section is a cartographic unit comprising 1–9 census blocks, consisting of built or unbuilt lots bounded by public roads or pedestrian walkways (27). We calculated expected values of dengue and Zika by census sections by using a similar method to the one applied at the department level. Using the 2016 population projections provided by the Colombia statistical office, we calculated incidence rates for dengue and Zika by 5-year patient age groups and sex for the study period. Next, we multiplied the incidence rates for the population structure (by sex and age group) of each census section obtained from the Colombia Census and aggregated the age- and sex-specific expected counts per census section to obtain the standardized expected values of dengue and Zika per census section.
Joint Models for Estimating Relative Risk
We assumed that the observed counts of dengue or Zika aggregated by area (87 municipalities at the department level or 293 census sections at the city level) follow a Poisson distribution, with mean parameter equal to the product of the disease- and area-specific expected values and RR. The logarithm of the RR is the additive result of disease- and area-specific random effects accounting for the uncorrelated and clustered spatial patterns of risk and possibly covariates (30). Random effects for spatially clustered patterns of risk are unobserved variables recovering risk autocorrelation between adjacent areas, indicating that risk in one area is highly associated with risk in neighboring areas. The lack of spatial risk autocorrelation is accounted for by spatial uncorrelated random effects (5,31).
A joint model of RR for dengue and Zika defines a structure for the nature of the spatial association between the diseases (5). To that end, we fitted 8 Bayesian Poisson models (5,31) of joint estimation of RR to the dengue and Zika data at the department and city levels. Formulation of the statistical model is available in the Appendix. Here we describe the spatial patterns of risk for every joint model.
Model 1 contains area- and disease-specific random effects capturing uncorrelated spatial patterns of dengue and Zika risk. Choosing this model implies that dengue and Zika high-risk areas are not associated with each other and show no clustering (Figure 2, panel A).
Model 2 incorporates area- and disease-specific random effects capturing uncorrelated spatial patterns of dengue and Zika risk, where the random effects of both diseases are spatially associated. Model 2 assumes that the random effects for uncorrelated spatial patterns are linearly associated for both diseases; thus, dengue and Zika high-risk areas occur at the same position (Figure 2, panel B).
Model 3 contains area- and disease-specific random effects representing spatially clustered patterns of dengue and Zika risk, where the random effects are not associated between diseases. In this model, dengue high-risk areas are clustered and Zika high-risk areas are clustered, but dengue and Zika high-risk clustered areas are not spatially associated (Figure 2, panel C).
Model 4 contains area- and disease-specific random effects revealing spatially clustered patterns of dengue and Zika risk, where the random effects are linearly associated between diseases. In this model, dengue and Zika high-risk areas are spatially associated; thus, there are spatially clustered patterns of dengue and Zika high-risk areas at the same spatial locations (Figure 2, panel D).
Model 5 incorporates area- and disease-specific random effects revealing uncorrelated spatial patterns of dengue and Zika risk, and the spatial association between both diseases is modeled by using shared components of clustered spatial patterns of dengue and Zika risk. In this model, dengue high-risk areas are next to Zika high-risk areas, but dengue high-risk areas are not clustered and Zika high-risk areas are not clustered (Figure 2, panel E).
Model 6 incorporates area- and disease-specific random effects revealing spatially clustered patterns of dengue and Zika high risk, and the spatial association between both diseases is accounted for by using shared random effects of spatially clustered patterns of dengue and Zika high risk. In this model, spatially clustered patterns of dengue high-risk areas are adjacent to spatially clustered patterns of Zika high-risk areas (Figure 2, panel F).
Model 7 contains area- and disease-specific random effects accounting for spatially clustered patterns of Zika high risk conditioned on random effects for spatially clustered patterns of dengue high risk. Thus, dengue high-risk areas are determinants of the presence of Zika high-risk areas (Figure 2, panel G).
Model 8 contains area- and disease-specific random effects accounting for spatially clustered patterns of dengue high risk conditioned on random effects for spatially clustered patterns of Zika high risk. Thus, Zika high-risk areas are determinants of the presence of dengue high-risk areas (Figure 2, panel H).
We summarized the association structure of the joint models of RR (Table 3); every model captures the nature of the spatial association between dengue and Zika risk. We fitted the Bayesian Poisson models by applying Markov chain Monte Carlo simulations and using WinBUGS 1.4 software (32) for Bayesian analysis. We selected noninformative prior distributions for the parameters and hyperparameters; model specifications are presented in the Appendix. Every model was fitted by using 100,000 burn-in iterations, 10,000 iterations for inferences, a thinning of 10, three chains, and 1,000 iterations per chain for final inferences. For model selection, we used the deviance information criterion (DIC) (33), for which the lowest DIC estimates the model with the best predictions subject to the DIC difference between the model with minimum DIC and the next model being >5, as substantial evidence in favor of the first model with respect to the second (34).
For the Santander department, the analysis included 10,051 Zika patients (63.1% female, 36.9% male) and 7,891 dengue patients (48.6% female, 51.4% male). The analysis of Bucaramanga city included 3,662 Zika patients (61.2% female, 38.8% male) and 2,470 dengue patients (49.3% female, 50.7% male). Figure 3 shows the age- and sex-specific incidence rates for dengue and Zika in Santander (Figure 3, panel A) and Bucaramanga (Figure 3, panel B). At the department and city levels, reported Zika cases were consistently higher among female patients in the 10–14 and 55–59 year age groups, and reported dengue cases were highest among patients of both sexes in the 5–9 and 20–24 year age groups. The age- and sex-specific incidence rates were slightly higher at the city level than the department level.
We mapped the incidence rates (cases/100,000 population) and the standardized incidence ratios (observed values/expected values) for dengue and Zika (Figure 4). At the department level, the incidence rate for Zika was 0–3,688 cases/100,000 population; for dengue, 0–4,285 cases/100,000 population (Figure 4, panel A). At the department level, the incidence rate for dengue was highest in the southeastern municipalities; for Zika, in the northeastern municipalities. The standardized incidence ratios for dengue and Zika at the department level follow the findings of the incidence rate map; however, the standardized incidence ratio accounts for the expected number of cases, so some areas with a high observed incidence rate do not show a high standardized incidence ratio (Figure 4, panel B). We determined heterogeneous incidence rates for dengue and Zika at the city level (Figure 4, panel C); some high incidence rate census sections are in the northern and central areas of the city. We also determined the standardized incidence ratio per census section (Figure 4, panel D); as before, the standardized incidence ratio map shows the findings of the incidence rate, smoothing the geographic incidence estimates by census sections in Bucaramanga.
We compiled the results of the selection statistics for the joint models of RR at the department level (Table 4). Based on the lowest DIC, model 5 (disease-specific random effects for uncorrelated spatial patterns of risk and shared random effects of spatially clustered patterns for both diseases) is the selected model (deviance 808.3, DIC 942.9) for Santander; at the city level (Table 5), model 7 (Zika risk distribution conditioned by dengue risk) is the selected final model (deviance 2,869.7, DIC 3,119.3) for Bucaramanga. We included the DIC differences between models, showing that after the final selected model, models 7 and 8 were the closest models at the department level; models 8 and 4, at the city level (Tables 4, 5).
Figure 5 displays the posterior mean RR and the lower bound of the 95% credible interval (CrI) of RR >1 (95% CrI RR >1) of dengue and Zika obtained from the selected final models in Tables 4 and Tables 5. In Santander, the posterior mean RR (Figure 5, panel A) shows the standardized incidence ratio pattern displayed in Figure 4, panel A; as a byproduct of the modeling process, Figure 5, panel B, shows the municipalities with 95% probability of RR higher than that for the other municipalities. Most of the dengue and Zika high-risk municipalities differ in risk distribution: Zika high-risk municipalities are in the northern part of the department, and dengue high-risk municipalities are in the southern to northeastern parts. For Bucaramanga, the dengue and Zika posterior mean RR maps revealed the nonclustered risk pattern of the diseases (Figure 5, panel C), also displayed by the standardized incidence ratio map in Figure 4, panel C. However, the model shrinks the posterior mean RR, capturing the close association between Zika and dengue high-risk distribution per census sections. We identified the census sections with 95% probability of RR being higher than in the other areas (Figure 5, panel D), showing dengue high-risk census sections associated with Zika high-risk census sections at the city level.
Our study illustrates the joint estimation of RR for dengue and Zika at the department and city levels in Colombia. A battery of joint models of RR captured the spatial association between the diseases during the 2015–2016 Zika outbreak. The model selection process was based on DIC statistics; and we assessed the model’s goodness-of-fit by using residual analysis, fitted-observed scatter plots, and the posterior predictive checks of overdispersion recovery (Appendix).
At the department level, the selected model 5 reveals spatially clustered patterns of high-risk municipalities for both diseases, while keeping disease- and area-specific uncorrelated spatial patterns of high-risk municipalities, precluding selection of other feasible but not optimal models, such as models 7 and 8, containing area- and disease-specific spatially clustered patterns of high risk. The selected model shows that dengue- and Zika-specific high-risk municipalities are not clustered but that dengue high-risk municipalities are next to Zika high-risk municipalities.
At the city level, the selected model 7 contains conditional random effects for spatially clustered patterns of high-risk census sections, where Zika high-risk census sections are conditioned on dengue high-risk census sections; thus, Zika high-risk census sections are highly associated with dengue high-risk census sections. Models 8 and 4 were other feasible but not optimal options; although both models reveal the spatially clustered distribution of risk, the spatial data distributions do not support strong spatial association of dengue high-risk areas at the same locations as Zika high-risk areas. Model 7 shows that dengue or Zika high-risk areas are spatially clustered; dengue and Zika high-risk census sections are near other high-risk census sections. Thus, at the city level, clustered census sections display favorable conditions for transmission of both diseases, justifying a deeper study of environmental, infrastructural, and socioeconomic conditions associated with dengue and Zika high risk in those areas.
Model-based estimates of posterior means and lower bounds of CrIs of RR were represented in risk maps. These maps identified areas with a given risk probability and highlighted municipalities or census sections with high probable risk for dengue or Zika.
The area- and disease-specific risk estimates from the joint models accounting for the spatial association of both diseases (models 5 [department level] and model 7 [city level]) were more accurate than the estimates recovered ignoring the association of both diseases. It would be useful to compare risk estimates from joint models, with estimates ignoring the association structure of cocirculating arboviral diseases. For instance, Krystosik et al. (22) estimated the combined risk for dengue, Zika, and chikungunya but did not provide disease-specific risk estimates; Costa et al. (35) found associations in the spatial distribution of dengue, Zika, and chikungunya but did not use the information on the diseases’ association to improve the accuracy of the risk estimates. The special characteristics of the joint modeling of cocirculating arboviruses provide an epidemiologic tool for transmission control and disease mitigation (36).
Our study has some limitations. Although notification of dengue and Zika is compulsory in Colombia, a large proportion of reported cases are diagnosed by clinical signs and not laboratory confirmed. Because we used suspected and confirmed dengue and Zika cases, some cases included in the study may have been misdiagnosed. Another potential source of study bias is underreporting, as shown by Romero-Vega et al. (37) for dengue in Colombia; the National Health Institute of Colombia calculated an underreporting rate of 49% for Zika in a high-incidence town in Colombia (38). However, we used the same data that the Colombia authorities use to generate public health information for making decisions about controlling and preventing activities of public and private health institutions, extending the current information produced by the public health surveillance system, supporting surveillance activities for Zika and dengue, providing information for monitoring the geographic distribution of both diseases, and characterizing spatially the disease distribution in the population (39).
Determinants of dengue and Zika risk as covariates within the joint models (e.g., using datasets such as the ecological and environmental spatial dataset developed by Siraj et al.  for Colombia) remain to be elucidated. Other joint models available in the spatial analysis literature should be tested, jointly modeling other arboviral diseases such as chikungunya together with dengue and Zika and including joint models of RR of dengue and Zika within real-time surveillance platforms (41).
In summary, our method for mapping cocirculating dengue and Zika provides a tool for describing disease distribution, based on the epidemiologic complexities of both diseases. Information on the association between diseases is of value, especially in areas where multiple arboviruses cocirculate, and can be used to improve inferences and interpretations and thus contribute to informed public health decision making.
Mr. Martínez-Bello is a PhD student in statistics and optimization. His research interests are spatial analysis of arboviral diseases, health and economics geography, and Bayesian statistics.
A.L.-Q. was supported by the Ministerio de Economía y Competitividad (research grant MTM2016-77501-P, jointly financed with the European Regional Development Fund). D.A.M.-B. was supported by the Colombian Administrative Department of Science and Technology (grant 646-2014) for doctoral studies abroad.
- Plourde AR, Bloch EM. A literature review of Zika virus. Emerg Infect Dis. 2016;22:1185–92. DOIPubMedGoogle Scholar
- Villar LA, Rojas DP, Besada-Lombana S, Sarti E. Epidemiological trends of dengue disease in Colombia (2000-2011): a systematic review. PLoS Negl Trop Dis. 2015;9:
e0003499. DOIPubMedGoogle Scholar
- National Health Institute. Event report: dengue, 2016 [in Spanish] [cited 2019 Apr 1]. http://www.ins.gov.co/buscador-http://www.ins.gov.co/buscador-eventos/Informesdeevento/Dengue%202016.pdf
- National Health Institute of Colombia. Weekly epidemiological bulletin number 52 of 2016, 25 December–31 December [in Spanish] [cited 2019 Apr 1]. http://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/2016%20Bolet%C3%ADn%20epidemiol%C3%B3gico%20semana%2052%20-.pdf
- Banerjee S, Carlin BP, Gelfand AE. Hierarchical modeling and analysis for spatial data. In: Bunea F, Isham V, Keiding N, Louis T, Smith RL, Tong H, editors. Chapman & Hall/CRC Monographs on Statistics & Applied Probability. 2nd ed. Boca Raton (FL): Taylor & Francis Group; 2014. p. 305–24.
- Racloz V, Ramsey R, Tong S, Hu W. Surveillance of dengue fever virus: a review of epidemiological models and early warning systems. PLoS Negl Trop Dis. 2012;6:
e1648. DOIPubMedGoogle Scholar
- Louis VR, Phalkey R, Horstick O, Ratanawong P, Wilder-Smith A, Tozan Y, et al. Modeling tools for dengue risk mapping - a systematic review. Int J Health Geogr. 2014;13:50. DOIPubMedGoogle Scholar
- Ferreira GS, Schmidt AM. Spatial modelling of the relative risk of dengue fever in Rio de Janeiro for the epidemic period between 2001 and 2002. Braz J Probab Stat. 2006;20:29–47.
- Martínez-Bello DA, López-Quílez A, Torres Prieto A. Relative risk estimation of dengue disease at small spatial scale. Int J Health Geogr. 2017;16:31. DOIPubMedGoogle Scholar
- Restrepo AC, Baker P, Clements ACA. National spatial and temporal patterns of notified dengue cases, Colombia 2007-2010. Trop Med Int Health. 2014;19:863–71. DOIPubMedGoogle Scholar
- Martínez-Bello D, López-Quílez A, Torres Prieto A. Spatiotemporal modeling of relative risk of dengue disease in Colombia. Stochastic Environ Res Risk Assess. 2018;32:1587–601. DOIGoogle Scholar
- Rodriguez-Morales AJ, Patiño-Cadavid LJ, Lozada-Riascos CO, Villamil-Gómez WE. Mapping Zika in municipalities of one coastal department of Colombia (Sucre) using geographic information systems during the 2015-2016 outbreak: implications for public health and travel advice. Int J Infect Dis. 2016;48:70–2. DOIPubMedGoogle Scholar
- Rodriguez-Morales AJ, Galindo-Marquez ML, García-Loaiza CJ, Sabogal-Roman JA, Marin-Loaiza S, Ayala AF, et al. Mapping Zika virus infection using geographical information systems in Tolima, Colombia, 2015-2016. F1000 Res. 2016;5:568. DOIPubMedGoogle Scholar
- Rodriguez-Morales AJ, García-Loaiza CJ, Galindo-Marquez ML, Sabogal-Roman JA, Marin-Loaiza S, Lozada-Riascos CO, et al. Zika infection GIS-based mapping suggest high transmission activity in the border area of La Guajira, Colombia, a northeastern coast Caribbean department, 2015-2016: Implications for public health, migration and travel. Travel Med Infect Dis. 2016;14:286–8. DOIPubMedGoogle Scholar
- Rodriguez-Morales AJ, Haque U, Ball J, García-Loaiza CJ, Galindo-Marquez ML, Sabogal-Roman JA, et al. Spatial distribution of Zika virus infection in Northeastern Colombia. Infez Med. 2017;25:241–6.PubMedGoogle Scholar
- Rodriguez-Morales AJ, Ruiz P, Tabares J, Ossa CA, Yepes-Echeverry MC, Ramirez-Jaramillo V, et al. Mapping the ecoepidemiology of Zika virus infection in urban and rural areas of Pereira, Risaralda, Colombia, 2015-2016: Implications for public health and travel medicine. Travel Med Infect Dis. 2017;18:57–66. DOIPubMedGoogle Scholar
- Chien L-C, Lin R-T, Liao Y, Sy FS, Pérez A. Surveillance on the endemic of Zika virus infection by meteorological factors in Colombia: a population-based spatial and temporal study. BMC Infect Dis. 2018;18:180. DOIPubMedGoogle Scholar
- Li X, Liu T, Lin L, Song T, Du X, Lin H, et al. Application of the analytic hierarchy approach to the risk assessment of Zika virus disease transmission in Guangdong Province, China. BMC Infect Dis. 2017;17:65. DOIPubMedGoogle Scholar
- Campos MC, Dombrowski JG, Phelan J, Marinho CRF, Hibberd M, Clark TG, et al. Zika might not be acting alone: Using an ecological study approach to investigate potential co-acting risk factors for an unusual pattern of microcephaly in Brazil. PLoS One. 2018;13:
e0201452. DOIPubMedGoogle Scholar
- Aguiar BS, Lorenz C, Virginio F, Suesdek L, Chiaravalloti-Neto F. Potential risks of Zika and chikungunya outbreaks in Brazil: A modeling study. Int J Infect Dis. 2018;70:20–9. DOIPubMedGoogle Scholar
- Rodrigues NCP, Daumas RP, de Almeida AS, Dos Santos RS, Koster I, Rodrigues PP, et al. Risk factors for arbovirus infections in a low-income community of Rio de Janeiro, Brazil, 2015-2016. PLoS One. 2018;13:
e0198357. DOIPubMedGoogle Scholar
- Krystosik AR, Curtis A, Buritica P, Ajayakumar J, Squires R, Dávalos D, et al. Community context and sub-neighborhood scale detail to explain dengue, chikungunya and Zika patterns in Cali, Colombia. PLoS One. 2017;12:
e0181208. DOIPubMedGoogle Scholar
- Martínez-Bello DA, López-Quílez A, Torres Prieto A. Spatio-temporal modeling of Zika and dengue infections within Colombia. Int J Environ Res Public Health. 2018;15:1376. DOIPubMedGoogle Scholar
- Riou J, Poletto C, Boëlle PY. A comparative analysis of Chikungunya and Zika transmission. Epidemics. 2017;19:43–52. DOIPubMedGoogle Scholar
- Funk S, Kucharski AJ, Camacho A, Eggo RM, Yakob L, Murray LM, et al. Comparative analysis of dengue and Zika outbreaks reveals differences by setting and virus. PLoS Negl Trop Dis. 2016;10:
e0005173. DOIPubMedGoogle Scholar
- Pacheco O, Beltrán M, Nelson CA, Valencia D, Tolosa N, Farr SL, et al. Zika virus disease in Colombia—preliminary report. [cited 2019 Apr 15] https://www.nejm.org/doi/full/10.1056/NEJMoa1604037
- Administrative Department of National Statistics. Colombia. Direction of geostatistics, urban section level layer, National Geostatistical Framework, 2005 [in Spanish] [cited 2018 Nov 10]. http://www.dane.gov.co
- National Health Institute of Colombia. Protocol of public health surveillance, dengue, code: 210, 220, 580 [in Spanish] [cited 2018 Nov 10]. https://www.ins.gov.co/buscador-eventos/ZIKA%20Lineamientos/Dengue%20PROTOCOLO.pdf
- National Health Institute of Colombia. Protocol of public health surveillance, Zika, code 895 [in Spanish] [cited 2019 Apr 1]. http://www.ins.gov.co/buscador-eventos/Lineamientos/PRO%20Zika.pdf
- Besag J, York J, Mollie A. Bayesian image restoration with two applications in spatial statistics. Ann Inst Stat Math. 1991;43:1–59. DOIGoogle Scholar
- Ma H, Carlin BP. Bayesian multivariate areal Wombling for multiple disease boundary analysis [cited 2017 Oct 10]. http://www.biostat.umn.edu/~brad/software/mc.pdf
- Lunn D, Spiegelhalter D, Thomas A, Best N. The BUGS project: Evolution, critique and future directions. Stat Med. 2009;28:3049–67. DOIPubMedGoogle Scholar
- Spiegelhalter DJ, Best NG, Carlin BP, van der Linde A. Bayesian measures of model complexity and fit. Stat Methodol. 2002;64:583–639. DOIGoogle Scholar
- Spiegelhalter D, Thomas A, Best N, Lunn D. OpenBUGS user manual: advanced use of the BUGS language [cited 2017 Nov 12]. http://www.ins.gov.co/buscador-eventos/Informesdeevento/Dengue%202016.pdf
- Costa SDSB, Branco MDRFC, Aquino Junior J, Rodrigues ZMR, Queiroz RCS, Araujo AS, et al. Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil. Rev Inst Med Trop São Paulo. 2018;60:
e62. DOIPubMedGoogle Scholar
- Christofferson RC. Zika virus emergence and expansion: lessons learned from dengue and chikungunya may not provide all the answers. Am J Trop Med Hyg. 2016;95:15–8. DOIPubMedGoogle Scholar
- Romero-Vega L, Pacheco O, de la Hoz-Restrepo F, Díaz-Quijano FA. Evaluation of dengue fever reports during an epidemic, Colombia. Rev Saude Publica. 2014;48:899–905. DOIPubMedGoogle Scholar
- National Health Institute of Colombia. Subregister of Zika in Girardot, Cundinamarca, 2015–2016 [in Spanish] [cited 2018 Nov 15]. http://www.ins.gov.co/buscador-eventos/IQEN/Forms/AllItems.aspx
- Saiz J-C, Martín-Acebes MA, Bueno-Marí R, Salomón OD, Villamil-Jiménez LC, Heukelbach J, et al. Zika virus: what have we learnt since the start of the recent epidemic? Front Microbiol. 2017;8:1554. DOIPubMedGoogle Scholar
- Siraj AS, Rodriguez-Barraquer I, Barker CM, Tejedor-Garavito N, Harding D, Lorton C, et al. Spatiotemporal incidence of Zika and associated environmental drivers for the 2015-2016 epidemic in Colombia. Sci Data. 2018;5:
180073. DOIPubMedGoogle Scholar
- Jaramillo-Martínez GA, Vasquez-Serna H, Chavarro-Ordoñez R, Rojas-Gomez OF, Jimenez-Canizales CE, Rodriguez-Morales AJ. Ibagué Saludable: A novel tool of Information and Communication Technologies for surveillance, prevention and control of dengue, chikungunya, Zika and other vector-borne diseases in Colombia. J Infect Public Health. 2018;11:145–6. DOIPubMedGoogle Scholar
TablesCite This Article
Original Publication Date: May 03, 2019
1Current affiliation: Health and Environment Secretary, Bucaramanga, Colombia.
Table of Contents – Volume 25, Number 6—June 2019
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Please use the form below to submit correspondence to the authors or contact them at the following address:
Daniel A. Martínez-Bello, Department of Statistics and Operations Research, Faculty of Mathematics, University of Valencia, C/Dr. Moliner, 50 46100 Burjassot, Valencia, Spain