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Volume 25, Number 6—June 2019
Dispatch

Multirecombinant Enterovirus A71 Subgenogroup C1 Isolates Associated with Neurologic Disease, France, 2016–2017

Stéphanie Tomba Ngangas, Alexander Lukashev, Gwendoline Jugie, Olga Ivanova, Jean-Michel Mansuy, Catherine Mengelle, Jacques Izopet, Anne-Sophie L’honneur, Flore Rozenberg, David Leyssene, Denise Hecquet, Stéphanie Marque-Juillet, David Boutolleau, Sonia Burrel, Hélène Peigue-Lafeuille, Christine Archimbaud, Kimberley Benschop, Cécile Henquell, Audrey Mirand, and Jean-Luc BaillyComments to Author 
Author affiliations: Université Clermont Auvergne, Clermont-Ferrand, France (S. Tomba Ngangas, G. Jugie, H. Peigue-Lafeuille, C. Archimbaud, C. Henquell, A. Mirand, J.-L. Bailly); Sechenov University, Moscow, Russia (A. Lukashev, O. Ivanova); Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Moscow (O. Ivanova); Centre Hospitalier Universitaire de Toulouse, Toulouse, France (J.-M. Mansuy, C. Mengelle, J. Izopet); Assistance Publique-Hôspitaux de Paris Cochin, Paris, France (A.-S. L’honneur, F. Rozenberg); Centre Hospitalier de la Côte Basque, Bayonne, France (D. Leyssene); Centre Hospitalier Universitaire Amiens, Amiens, France (D. Hecquet); Centre Hospitalier de Versailles, Le Chesnay, France (S. Marque-Juillet); Assistance Publique-Hôspitaux de Paris Pitié-Salpêtrière-Charles Foix, Paris (D. Boutolleau, S. Burrel); CHU Clermont-Ferrand, Clermont-Ferrand (H. Peigue-Lafeuille, C. Archimbaud, C. Henquell, A. Mirand, J.-L. Bailly); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (K. Benschop)

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Table 1

Characteristics of patients with EV-A71 subgenogroup C1v2015 infection, France, 2016–2017*

Patient no. Specimen no. Care setting (City) Clinical diagnosis Specimen material Collection date Ct
01 01† Hospital (Toulouse) Acute meningitis Throat swab 2016 May 3 25
02 02 Hospital (Toulouse) Fever Nasopharyngeal aspirate 2016 May 19 30
02 03 Hospital (Toulouse) Fever Feces 2016 May 19 31
03 04 Hospital (Paris)‡ Fever Plasma 2016 Jun 7 37
04 05 Hospital (Paris)‡ Fever Plasma 2016 Jun 10 32
05 06 Hospital (Bayonne) Encephalitis Cerebrospinal fluid 2016 Jun 12 35
05 07† Hospital (Bayonne) Encephalitis Throat swab 2016 Jun 24 35
05 08 Hospital (Bayonne) Encephalitis Rectal swab 2016 Jun 24 35
06 09 Hospital (Toulouse) Infant fever Feces 2016 Jul 10 31
07 10† Hospital (Toulouse) Sepsis-like disease Throat swab 2016 Aug 10 24
07 11† Hospital (Toulouse) Sepsis-like disease Nasopharyngeal aspirate 2016 Aug 10 NR
08 12† Hospital (Paris)‡ Convulsions Nasopharyngeal aspirate 2016 Aug 11 28
09 13§ Ambulatory (Mirecourt) HFMD Mouth swab 2016 Aug 30 32
10 14† Ambulatory (Mirecourt) HFMD Throat swab 2016 Aug 30 29
11 15† Hospital (Paris)‡ Fever, hypotonia Blood 2016 Sep 5 30
12 16§ Hospital (Toulouse) Acute meningitis, HFMD Throat swab 2016 Sep 7 33
13 17† Ambulatory (Toulouse) HFMD Mouth swab 2016 Sep 14 29
14 18† Hospital (Paris)‡ Fever Feces 2016 Sep 27 20
15¶ 19† Daycare (Volvic) NR Feces 2016 Oct 4 29
16¶ 20† Daycare (Volvic) NR Feces 2016 Oct 4 31
17¶ 21† Daycare (Volvic) NR Feces 2016 Oct 4 31
18¶ 22† Daycare (Volvic) NR Feces 2016 Oct 4 29
19¶ 23† Daycare (Volvic) NR Feces 2016 Oct 4 31
20 24 Hospital (Toulouse) Sepsis-like disease Throat swab 2016 Oct 5 33
21 25 Hospital (Versailles) Diarrhea Cerebrospinal fluid 2016 Oct 9 35
22 26 Hospital (Toulouse) Acute meningitis, cerebellitis Throat swab 2016 Oct 10 36
22 27 Hospital (Toulouse) Acute meningitis, cerebellitis Feces 2016 Oct 10 30
23 28† Hospital (Toulouse) Fever Throat swab 2016 Oct 11 27
23 29 Hospital (Toulouse) Fever Feces 2016 Oct 12 29
24 30† Hospital (Amiens) Myelitis Nasopharyngeal swab 2016 Oct 18 30
24 31† Hospital (Amiens) Myelitis Feces 2016 Oct 20 33
25 32† Ambulatory (Montesson) Atypical HFMD, herpangina Throat swab 2017 Jul 3 22

*See Appendix Table 1 (https://wwwnc.cdc.gov/EID/article/25/6/18-1460-App1.pdf) for extended data, including GenBank accession nos. Ct, cycle threshold; EV-A71, enterovirus A71; HFMD, hand, foot and mouth disease; NR, not reported.
†Specimens for which the complete viral genomes (including the full 5′ and 3′ untranslated regions) were obtained.
‡Assistance Publique-Hôpitaux de Paris Cochin, Paris, France.
§Specimens for which partial genomes were obtained.
¶Patients 15-19 were children in the same daycare facility who had no evidence of clinical disease.

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Page created: May 20, 2019
Page updated: May 20, 2019
Page reviewed: May 20, 2019
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