Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 25, Number 7—July 2019
Research Letter

Identification of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain FC428, China

Shao-Chun Chen, Yan Han, Liu-Feng Yuan, Xiao-Yu Zhu, and Yue-Ping YinComments to Author 
Author affiliations: Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China (S.-C. Chen, Y. Han, X.-Y. Zhu, Y.-P. Yin); Chinese Center for Disease Control and Prevention, Nanjing (S.-C. Chen, Y. Han, X-.Y. Zhu, Y.-P. Yin); Beijing Ditan Hospital Capital Medical University, Beijing, China (L.-F. Yuan)

Main Article


Antimicrobial susceptibility and molecular characteristics of ceftriaxone-resistant Neisseria gonorrhoeae, China*

Strains Year Country (reference) Sexual contact history MIC, mg/L
Japan-FC428 2015 Japan (6) NA 0.5 8 0.5 >32 0.25 1 1903 1053 21 3435 60 233
Japan-FC460 2015 Japan (6) NA 0.5 8 0.5 >32 0.25 1 1903 1053 21 3435 60 233
China-BJ16148 2016 Aug China (this study) China 4 16 0.5 >32 0.25 1 1903 1053 21 3435 60 233
Denmark-GK124 2017 Jan Denmark (7) Denmark, China, Australia NA 8 0.5 >32 0.5 1 1903 1053 33 1614 60 233
Canada-47707 2017 Jan Canada (8) China, Thailand 4 16 1 >32 0.5 2 1903 1053 33 1614 60 233
Australia-A7846 2017 Apr Australia (9) Cambodia, Philippines 2 8 0.5 >32 0.25 NA 1903 1053 33 1614 60 233
Australia-A7536 2017 Aug Australia (9) China 4 8 0.5 >32 0.25 NA 1903 9300 21 15925 60 233

*AZI, azithromycin; CEF, cefixime; CIP, ciprofloxacin; CRO, ceftriaxone; MLST, multilocus sequence typing; NA, not available; NG-MAST, N. gonorrhoeae multiantigen sequence typing; NG-STAR, N. gonorrhoeae sequence typing for antimicrobial resistance; SPT, spectinomycin; TET, tetracycline.

Main Article

  1. Yin  YP, Han  Y, Dai  XQ, Zheng  HP, Chen  SC, Zhu  BY, et al. Susceptibility of Neisseria gonorrhoeae to azithromycin and ceftriaxone in China: A retrospective study of national surveillance data from 2013 to 2016. PLoS Med. 2018;15:e1002499. DOIPubMedGoogle Scholar
  2. Chen  SC, Yin  YP, Chen  XS. Cephalosporin-resistant Neisseria gonorrhoeae clone, China. Emerg Infect Dis. 2018;24:8046. DOIPubMedGoogle Scholar
  3. Martin  IM, Ison  CA, Aanensen  DM, Fenton  KA, Spratt  BG. Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area. J Infect Dis. 2004;189:1497505. DOIPubMedGoogle Scholar
  4. Jolley  KA, Maiden  MC. BIGSdb: Scalable analysis of bacterial genome variation at the population level. BMC Bioinformatics. 2010;11:595. DOIPubMedGoogle Scholar
  5. Demczuk  W, Sidhu  S, Unemo  M, Whiley  DM, Allen  VG, Dillon  JR, et al. Neisseria gonorrhoeae sequence typing for antimicrobial resistance, a novel antimicrobial resistance multilocus typing scheme for tracking global dissemination of N. gonorrhoeae strains. J Clin Microbiol. 2017;55:145468. DOIPubMedGoogle Scholar
  6. Nakayama  S, Shimuta  K, Furubayashi  K, Kawahata  T, Unemo  M, Ohnishi  M. New ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain with a novel mosaic penA gene isolated in Japan. Antimicrob Agents Chemother. 2016;60:433941. DOIPubMedGoogle Scholar
  7. Terkelsen  D, Tolstrup  J, Johnsen  CH, Lund  O, Larsen  HK, Worning  P, et al. Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017. Euro Surveill. 2017;22:22. DOIPubMedGoogle Scholar
  8. Lefebvre  B, Martin  I, Demczuk  W, Deshaies  L, Michaud  S, Labbé  AC, et al. Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017. Emerg Infect Dis. 2018;24:3813. DOIPubMedGoogle Scholar
  9. Lahra  MM, Martin  I, Demczuk  W, Jennison  AV, Lee  KI, Nakayama  SI, et al. Cooperative recognition of internationally disseminated ceftriaxone-resistant Neisseria gonorrhoeae strain. Emerg Infect Dis. 2018;24:73540. DOIPubMedGoogle Scholar
  10. Wi  T, Lahra  MM, Ndowa  F, Bala  M, Dillon  JR, Ramon-Pardo  P, et al. Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action. PLoS Med. 2017;14:e1002344. DOIPubMedGoogle Scholar

Main Article

Page created: March 22, 2019
Page updated: March 22, 2019
Page reviewed: March 22, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.