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Volume 26, Number 12—December 2020

Outbreaks of Highly Pathogenic Avian Influenza (H5N6) Virus Subclade in Swans, Xinjiang, Western China, 2020

Yanbing Li, Minghui Li, Yulei Li, Jingman Tian, Xiaoli Bai, Cen Yang, Jianzhong Shi, Ridengcaicike Ai, Weidong Chen, Wentao Zhang, Jie Li, Yufei Kong, Yuntao Guan, and Hualan ChenComments to Author 
Author affiliations: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China (Y. Li, M. Li, Y. Li, J. Tian, X. Bai, J. Shi, C. Yang, Y. Kong, Y. Guan, H. Chen); Preventive and Control Center for Animal Disease of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang Wei Autonomous Region, China (R. Ai, J. Li); Preventive and Control Center for Animal Disease of Xinjiang Crops, Urumqi (W. Zhang, J. Li)

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Table 2

Virulence related molecular markers detected in the WS/XJ/1/2020 (H5N6) virus detected among migratory whooper swans (Cygnus cygnus) and mute swans (C. olor), Xinjiang Province, China, January 2020

Protein Amino acid/motif Phenotypic consequences
Cleavage site motif: -RRKR¯G-
Polybasic cleavage motif sequence required for high pathogenicity of avian influenza viruses in chickens
Stalk deletion 58–68
Increased virulence in mice
Polymerase acidic protein
Increased polymerase activity in mammalian cells
Matrix protein 1
30D Increased virulence in mice
Increased virulence in mice
Nonstructural protein 1 80–84 deletion Increased virulence in mice
42S Increased virulence in mice
98F Increased virulence in mice
101M Increased virulence in mice
222–225 ESEV (PDZ domain) Increased virulence in mice

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Page created: September 02, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
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